Browsing Recerca: articles, congressos, llibres by Subject "Regulació genètica"

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Browsing Recerca: articles, congressos, llibres by Subject "Regulació genètica"

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  • Encinar del Dedo, Javier; Gabrielli, Natalia, 1978-; Carmona, Mercè; Ayté del Olmo, José; Hidalgo Hernando, Elena (Public Library of Science, 2015)
    Iron is an essential cofactor, but it is also toxic at high levels. In Schizosaccharomyces pombe, the sensor glutaredoxin Grx4 guides the activity of the repressors Php4 and Fep1 to mediate a complex transcriptional response ...
  • Agirre Ortiz de Guzmán, Eneritz, 1983-; Bellora Pereyra, Nicolás; Alló, Mariano; Pagès Pinós, Amadís; Bertucci, Paola; Kornblihtt, Alberto R.; Eyras Jiménez, Eduardo (BioMed Central, 2015)
    BACKGROUND: Alternative splicing is primarily controlled by the activity of splicing factors and by the elongation of the RNA polymerase II (RNAPII). Recent experiments have suggested a new complex network of splicing ...
  • Paulo, Esther; García Santamarina, Sarela, 1978-; Calvo, Isabel A.; Carmona, Mercè; Boronat, Susanna; Domènech, Alba; Ayté del Olmo, José; Hidalgo Hernando, Elena (Wiley-Blackwell, 2014)
    The main peroxiredoxin in Schizosaccharomyces pombe, Tpx1, is important to sustain aerobic growth, and cells lacking this protein are only able to grow on solid plates under anaerobic conditions. We have found that deletion ...
  • Ruíz Romero, Marina; Blanco, Enrique; Paricio, Nuria; Serras Rigalt, Florenci; Corominas Guiu, Montserrat (EMBO Press, 2015)
    The Drosophila transcription factor Cabut/dTIEG (Cbt) is a growth regulator, whose expression is modulated by different stimuli. Here, we determine Cbt association with chromatin and identify Yorkie (Yki), the transcriptional ...
  • Ounzain, Samir; Micheletti, Rudi; Arnan Ros, Carme; Plaisance, Isabelle; Cecchi, Dario; Schroen, Blanche; Reverter, Ferran; Alexanian, Michael; Gonzales, Christine; Ng, Shi Yan; Bussotti, Giovanni, 1983-; Pezzuto, Iole; Notredame, Cedric; Heymans, Stephane; Guigó Serra, Roderic; Johnson, Rory; Pedrazzini, Thierry (Elsevier, 2015)
    Long noncoding RNAs (lncRNAs) are emerging as important regulators of developmental pathways. However, their roles in human cardiac precursor cell (CPC) remain unexplored. To characterize the long noncoding transcriptome ...
  • Wright, Roni H.G.; Castellano, Giancarlo; Bonet Martínez, Jaume, 1982-; Le Dily, Francois; Font Mateu, Jofre; Ballaré, Cecilia; Nacht, A. Silvina; Soronellas, Daniel; Oliva Miguel, Baldomero; Beato, Miguel (Cold Spring Harbor Laboratory Press (CSHL Press), 2012)
    Eukaryotic gene regulation implies that transcription factors gain access to genomic information via poorly understood processes involving activation and targeting of kinases, histone-modifying enzymes, and chromatin ...
  • Cowled, Christopher; Stewart, Cameron R; Likic, Vladimir A; Friedländer, Marc R; Tachedjian, Mary; Jenkins, Kristie A; Tizard, Mark L; Cottee, Pauline; Marsh, Glenn A; Zhou, Peng; Baker, Michelle L; Bean, Andrew G; Wang, Lin-fa (BioMed Central, 2014)
    Background: Bats are a major source of new and emerging viral diseases. Despite the fact that bats carry and shed highly pathogenic viruses including Ebola, Nipah and SARS, they rarely display clinical symptoms of infection. ...
  • Gerstein, Mark B.; Djebali, Sarah; Lagarde, Julien; Pervouchine, Dmitri D.; Guigó Serra, Roderic; Tanzer, Andrea; Waterston, Robert (Nature Publishing Group, 2014)
    The transcriptome is the readout of the genome. Identifying common features in it across distant species can reveal fundamental principles. To this end, the ENCODE and modENCODE consortia have generated large amounts of ...
  • Abril Ferrando, Josep Francesc; Castelo Valdueza, Robert; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press-CSHL Press, 2005)
    We have carried out an initial analysis of the dynamics of the recent evolution of the splice-sites sequences on a large collection of human, rodent (mouse and rat), and chicken introns. Our results indicate that the ...
  • Tamborero, David; González Pérez, Abel; Pérez Llamas, Christian, 1976-; Déu Pons, Jordi; Kandoth, Cyriac; Reimand, Jüri; Lawrence, Michael S.; Getz, Gad; Bader, Gary D.; Ding, Li; López Bigas, Núria (Nature Publishing Group, 2013)
    With the ability to fully sequence tumor genomes/exomes, the quest for cancer driver genes can now be undertaken in an unbiased manner. However, obtaining a complete catalog of cancer genes is difficult due to the heterogeneous ...
  • Uzkudun, Manu; Marcon, Luciano, 1983-; Sharpe, James (Wiley Blackwell, 2015)
    Parameter optimization coupled with model selection is a convenient approach to infer gene regulatory networks from experimental gene expression data, but so far it has been limited to single cells or static tissues where ...
  • Munteanu, Andreea; Cotterell, James; Solé Vicente, Ricard, 1962-; Sharpe, James (Nature Publishing Group, 2014)
    Interpreting a morphogen gradient into a single stripe of gene-expression is a fundamental unit of patterning in early embryogenesis. From both experimental data and computational studies the feed-forward motifs stand out ...
  • Plass Pórtulas, Mireya, 1982-; Eyras Jiménez, Eduardo (BioMed Central, 2006)
    Background: Alternatively spliced exons play an important role in the diversification of gene function in most metazoans and are highly regulated by conserved motifs in exons and introns. Two contradicting properties have ...
  • Jiménez, Alba; Cotterell, James; Munteanu, Andreea; Sharpe, James (Cold Spring Harbor Laboratory Press, 2015)
    To what extent does the dynamical mechanism producing a specific biological phenotype bias the ability to evolve into novel phenotypes? We use the interpretation of a morphogen gradient into a single stripe of gene expression ...
  • Pervouchine, Dmitri D.; Djebali, Sarah; Breschi, Alessandra; Prieto Barja, Pablo; Lagarde, Julien; Bussotti, Giovanni, 1983-; Monlong, Jean; Notredame, Cedric; Guigó Serra, Roderic; Gingeras, Thomas R. (Nature Pub. Group, 2015)
    Mice have been a long-standing model for human biology and disease. Here we characterize, by RNA sequencing, the transcriptional profiles of a large and heterogeneous collection of mouse tissues, augmenting the mouse ...
  • Meunier, Sylvain; Shvedunova, Maria; Van Nguyen, Nhuong; Ávila, Leonor; Vernos, Isabelle, 1959-; Akhtar, Asifa (Nature Publishing Group, 2015)
    The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, ...
  • Sanz Pamplona, Rebeca; Aragüés Peleato, Ramón; Driouch, Keltouma; Martín, Berta; Oliva Miguel, Baldomero; Gil, Miguel; Boluda, Susana; Fernández, Pedro L.; Martínez, Antonio; Moreno, Víctor; Acebes, Juan J.; Lidereau, Rosette; Reyal, Fabien; Van de Vijver, Marc J.; Sierra, Angels (Elsevier, 2011)
    The increasing incidence of breast cancer brain metastasis in patients with otherwise well-controlled systemic cancer is a key challenge in cancer research. It is necessary to understand the properties of brain-tropic tumor ...
  • Buxadé, Maria; Lunazzi, Giulia; Minguillón Pedreño, Jordi; Iborra, Salvador; Berga-Bolaños, Rosa; del Val, Margarita; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Rockefeller University Press, 2012)
    Toll-like receptors (TLRs) engage networks of transcriptional regulators to induce genes essential for antimicrobial immunity. We report that NFAT5, previously characterized as an osmostress responsive factor, regulates ...
  • Chisaguano, Aida M.; Montes, Rosa; Pérez Berezo, Teresa; Castellote, Ana Isabel; Guerendiain, Marcela; Bustamante Pineda, Mariona; Morales, Eva; García Esteban, Raquel; Sunyer Deu, Jordi; Franch, Àngels; López Sabater, M. Carmen (Public Library of Science (PLoS), 2013)
    Background: It is unknown if changes in the gene expression of the desaturase and elongase enzymes are associated with abnormal n-6 long chain polyunsaturated fatty acid (LC-PUFA) levels in children with atopic eczema (AE). ...
  • Casals López, Ferran; Sikora, Martin, 1976-; Laayouni, Hafid, 1968-; Montanucci, Ludovica, 1978-; Muntasell, Aura; Lazarus, Ross; Calafell i Majó, Francesc; Awadalla, Philip; Netea, Mihai G; Bertranpetit, Jaume, 1952- (BioMed Central, 2011)
    Background: Pathogens have represented an important selective force during the adaptation of modern human populations to changing social and other environmental conditions. The evolution of the immune system has therefore ...

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