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DREAM controls the on/off switch of specific activity-dependent transcription pathways

Mellström, Britt; Sahún, Ignasi; Ruiz Nuño, Ana; Murtra, Patricia; Gómez Villafuertes, Rosa; Savignac, Magalí; Oliveros, Juan C.; González, Paz; Kastanauskaite, Asta; Knafo, Shira; Zhuo, Min; Higuera Matas, Alejandro; Errington, Michael L.; Maldonado, Rafael, 1961-; De Felipe, Javier; Jefferys, John G.R.; Bliss, Tim V. P.; Dierssen, Mara; Naranjo, José R. (American Society for Microbiology, 2014)

Changes in nuclear Ca(2+) homeostasis activate specific gene expression programs and are central to the acquisition and storage of information in the brain. DREAM (downstream regulatory element antagonist modulator), also ...
KChIP3 coupled to Ca2+ oscillations exerts a tonic brake on baseline mucin release in the colon

Cantero Recasens, Gerard, 1984-; Butnaru, Cristian M.; Valverde, M. A. (Miguel Ángel), 1963-; Naranjo, José R.; Brouwers, Nathalie; Malhotra, Vivek (eLife, 2018)

Regulated mucin secretion from specialized goblet cells by exogenous agonist-dependent (stimulated) and -independent (baseline) manner is essential for the function of the epithelial lining. Over extended periods, baseline ...