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Visualitza Recerca: articles, congressos, llibres per autoria "Nadal Clanchet, Eulàlia de"

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A genetic analysis reveals novel histone residues required for transcriptional reprogramming upon stress

Viéitez Manrique, Cristina, 1984-; Martínez Cebrián, Gerard, 1992-; Solé, Carme; Böttcher, René; Potel, Clement M.; Savitski, Mikhail M.; Onnebo, Sara; Fabregat, Marc; Shilatifard, Ali; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Oxford University Press, 2020)

Cells have the ability to sense, respond and adapt to environmental fluctuations. Stress causes a massive reorganization of the transcriptional program. Many examples of histone post-translational modifications (PTMs) have ...
A genome-wide functional screen identifies enhancer and protective genes for amyloid beta-peptide toxicity

Picón-Pagès, Pol; Bosch Morató, Mònica, 1986-; Subirana, Laia; Rubio-Moscardó, Francisca; Guivernau Almazán, Biuse, 1988-; Fanlo-Ucar, Hugo; Zeylan, Melisa Ece; Senyuz, Simge; Herrera-Fernández, Víctor; Vicente García, Rubén, 1978-; Fernández-Fernández, José Manuel, 1967-; García Ojalvo, Jordi; Gursoy, Attila; Keskin, Ozlem; Oliva Miguel, Baldomero; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de; Muñoz López, Francisco José, 1964- (MDPI, 2023)

Alzheimer's disease (AD) is known to be caused by amyloid β-peptide (Aβ) misfolded into β-sheets, but this knowledge has not yet led to treatments to prevent AD. To identify novel molecular players in Aβ toxicity, we carried ...
A novel mechanism for the prevention of transcription replication conflicts

Canal de Torres, Berta, 1988-; Duch, Alba; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Taylor & Francis, 2018)

Transcription and replication complexes can coincide in space and time. Such coincidences may result in collisions that trigger genomic instability. The phosphorylation of Mrc1 by different signaling kinases is part of a ...
Control of Cdc28 CDK1 by a stress-induced lncRNA

Nadal Ribelles, Mariona, 1984-; Solé, Carme; Xu, Zhenyu; Steinmetz, Lars M.; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Elsevier, 2014)

Genomic analysis has revealed the existence of a large number of long noncoding RNAs (lncRNAs) with different functions in a variety of organisms, including yeast. Cells display dramatic changes of gene expression upon ...
Control of Ubp3 ubiquitin protease activity by the Hog1 SAPK modulates transcription upon osmostress

Solé, Carme; Nadal Ribelles, Mariona, 1984-; Kraft, Claudine; Peter, Matthias; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Nature Publishing Group, 2011)

Protein ubiquitylation is a key process in the regulation of many cellular processes. The balance between the activity of ubiquitin ligases and that of proteases controls the level of ubiquitylation. In response to ...
Data-driven identification of inherent features of eukaryotic stress-responsive genes

Latorre Doménech, Pablo, 1993-; Böttcher, René; Nadal Ribelles, Mariona, 1984-; Li, Constance H.; Solé, Carme; Martínez Cebrián, Gerard, 1992-; Boutros, Paul C.; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Oxford University Press, 2022)

Living organisms are continuously challenged by changes in their environment that can propagate to stresses at the cellular level, such as rapid changes in osmolarity or oxygen tension. To survive these sudden changes, ...
Dealing with transcriptional outbursts during S phase to protect genomic integrity

Duch, Alba; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Elsevier, 2013)

Transcription during S phase needs to be spatially and temporally regulated to prevent collisions between the transcription and replication machineries. Cells have evolved a number of mechanisms to make both processes ...
Functional network analysis reveals the relevance of SKIIP in the regulation of alternative splicing by p38 SAPK

Carbonell Núñez, Caterina, 1987-; Ulsamer, Arnau; Vivori, Claudia, 1989-; Papasaikas, Panagiotis; Böttcher, René; Joaquin i Caudet, Manel; Miñana Gómez, Belén; Tejedor Vaquero, Juan Ramón, 1984-; Nadal Clanchet, Eulàlia de; Valcárcel, J. (Juan); Posas Garriga, Francesc (Elsevier, 2019)

Alternative splicing is a prevalent mechanism of gene regulation that is modulated in response to a wide range of extracellular stimuli. Stress-activated protein kinases (SAPKs) play a key role in controlling several steps ...
H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes

Nadal Ribelles, Mariona, 1984-; Mas Martín, Glòria; Millán Zambrano, Gonzalo; Solé, Carme; Ammerer, Gustav; Chávez, Sebastián; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Oxford University Press, 2015)

Chromatin remodeling is essential for proper adaptation to extracellular stimuli. The p38-related Hog1 SAPK is an important regulator of transcription that mediates chromatin remodeling upon stress. Hog1 targets the RSC ...
Hog1 activation delays mitotic exit via phosphorylation of Net1

Tognetti, Silvia; Jiménez, Javier; Viganò, Matteo; Duch, Alba; Queralt Badia, Ethel; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (National Academy of Sciences, 2020)

Adaptation to environmental changes is crucial for cell fitness. In Saccharomyces cerevisiae, variations in external osmolarity trigger the activation of the stress-activated protein kinase Hog1 (high-osmolarity glycerol ...
Hog1 bypasses stress-mediated down-regulation of transcription by RNA polymerase II redistribution and chromatin remodeling

Nadal Ribelles, Mariona, 1984-; Conde Pueyo, Núria, 1983-; Flores, Oscar; González-Vallinas Rostes, Juan, 1983-; Eyras Jiménez, Eduardo; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (BioMed Central, 2012)

Cells are subjected to dramatic changes of gene expression upon environmental changes. Stress/ncauses a general down-regulation of gene expression together with the induction of a set of stress-responsive/ngenes. The ...
Implementation of complex biological logic circuits using spatially distributed multicellular consortia

Macía, Javier; Manzoni, Romilde; Conde Pueyo, Núria, 1983-; Urrios Garcia, Arturo, 1990-; Nadal Clanchet, Eulàlia de; Solé Vicente, Ricard, 1962-; Posas Garriga, Francesc (Public Library of Science (PLoS), 2016)

Engineered synthetic biological devices have been designed to perform a variety of functions from sensing molecules and bioremediation to energy production and biomedicine. Notwithstanding, a major limitation of in vivo ...
Implementing re-configurable biological computation with distributed multicellular consortia

Canadell, David; Ortiz Vaquerizas, Nicolás; Mogas Díez, Sira; Nadal Clanchet, Eulàlia de; Macía, Javier; Posas Garriga, Francesc (Oxford University Press, 2022)

The use of synthetic biological circuits to deal with numerous biological challenges has been proposed in several studies, but its implementation is still remote. A major problem encountered is the complexity of the cellular ...
Interaction Dynamics Determine Signaling and Output Pathway Responses

Stojanovski, Klement; Ferrar, Tony; Benisty, Hannah, 1986-; Uschner, Friedemann; Delgado Blanco, Javier; Jimenez, Javier; Solé, Carme; Nadal Clanchet, Eulàlia de; Klipp, E., 1965-; Posas Garriga, Francesc; Serrano Pubull, Luis, 1982-; Kiel, Christina (Elsevier, 2017)

The understanding of interaction dynamics in signaling pathways can shed light on pathway architecture and provide insights into targets for intervention. Here, we explored the relevance of kinetic rate constants of a key ...
LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions

Serra, Selma A.; Stojakovic, Predrag; Amat, Ramon; Rubio Moscardó, Fanny; Latorre Doménech, Pablo, 1993-; Seisenbacher, Gerhard; Canadell, David; Böttcher, René; Aregger, Michael; Moffat, Jason; Nadal Clanchet, Eulàlia de; Valverde, M. A. (Miguel Ángel), 1963-; Posas Garriga, Francesc (National Academy of Sciences, 2021)

Regulation of cell volume is essential for tissue homeostasis and cell viability. In response to hypertonic stress, cells need rapid electrolyte influx to compensate water loss and to prevent cell death in a process known ...
Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts

Duch, Alba; Canal de Torres, Berta, 1988-; Barroso, Sonia I.; García Rubio, María Luisa; Seisenbacher, Gerhard; Aguilera, Andrés; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Nature Publishing Group, 2018)

Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have evolved strategies to prevent such conflicts. However, little is known regarding how cells cope ...
A novel role for lncRNAs in cell cycle control during stress adaptation

Solé, Carme; Nadal Ribelles, Mariona, 1984-; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Springer, 2015)

Eukaryotic cells have developed sophisticated systems to constantly monitor changes in the extracellular environment and to orchestrate a proper cellular response. To maximize survival, cells delay cell-cycle progression ...
Osmostress-induced gene expression--a model to understand how stress-activated protein kinases (SAPKs) regulate transcription

Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Wiley, 2015)

Adaptation is essential for maximizing cell survival and for cell fitness in response to sudden changes in the environment. Several aspects of cell physiology change during adaptation. Major changes in gene expression are ...
Phosphorylation and proteasome recognition of the mRNA-Binding protein Cth2 facilitates yeast adaptation to iron deficiency

Romero, Antonia M.; Martínez Pastor, Mar; Du, Gang; Solé, Carme; Carlos, María; Vergara, Sandra V.; Sanvisens, Nerea; Wohlschlegel, James A.; Toczyski, David P.; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de; Martínez-Pastor, María T.; Thiele, Dennis J.; Puig, Sergi (American Society for Microbiology, 2018)

Iron is an indispensable micronutrient for all eukaryotic organisms due to its participation as a redox cofactor in many metabolic pathways. Iron imbalance leads to the most frequent human nutritional deficiency in the ...
Positive feedback induces switch between distributive and processive phosphorylation of Hog1

Mosbacher, Maximilian; Lee, Sung Sik; Yaakov, Gilad; Nadal Ribelles, Mariona, 1984-; Nadal Clanchet, Eulàlia de; van Drogen, Frank; Posas Garriga, Francesc; Peter, Matthias; Claassen, Manfred (Nature Research, 2023)

Cellular decision making often builds on ultrasensitive MAPK pathways. The phosphorylation mechanism of MAP kinase has so far been described as either distributive or processive, with distributive mechanisms generating ...