Browsing Recerca: articles, congressos, llibres by Subject "Factors de transcripció"

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Browsing Recerca: articles, congressos, llibres by Subject "Factors de transcripció"

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  • Blanco, Enrique; Farré, Domènec; Albà Soler, Mar; Messeguer, Xavier; Guigó Serra, Roderic (Oxford University Press, 2006)
    Information about the genomic coordinates and the sequence of experimentally identified transcription factor binding sites is found scattered under a variety of diverse formats. The availability of standard collections of ...
  • Guigó Serra, Roderic; Sammeth, Michael; Foissac, Sylvain (Public Library of Science (PLoS), 2008)
    Understanding the molecular mechanisms responsible for the regulation of the transcriptome present in eukaryotic cells is one of the most challenging tasks in the postgenomic era. In this regard, alternative splicing (AS) ...
  • Morancho Armisen, Beatriz; Minguillón Pedreño, Jordi; Molkentin, Jeffery D.; López Rodríguez, M. Cristina; Aramburu, José (Aramburu Beltrán) (BioMed Central, 2008)
    Background: The transcription factor NFAT5/TonEBP regulates the response of mammalian cells to hypertonicity. However, little is known about the physiopathologic tonicity thresholds that trigger its transcriptional activity ...
  • Nicolay, Brandon N.; Bayarmagnai, Battuya; Islam, Abul, 1978-; López Bigas, Núria; Frolov, Maxim V. (Cold Spring Harbor Laboratory Press (CSHL Press), 2011)
    The Hippo signaling pathway regulates organ size homeostasis, while its inactivation leads to severe hyperplasia in flies and mammals. The transcriptional coactivator Yorkie (Yki) mediates transcriptional output of the ...
  • Celià-Terrassa, Toni; García de Herreros, Antonio; Thomson, Timothy M. (American Society for Clinical Investigation, 2012)
    Malignant progression in cancer requires populations of tumor-initiating cells (TICs) endowed with unlimited self renewal, survival under stress, and establishment of distant metastases. Additionally, the acquisition of ...
  • Lucena, Jaume; Pezzi, Susana; Aso Pérez, Ester; Valero, Maria C.; Carreiro, Candelas; Dubus, Pierre; Sampaio, Adriana; Segura Puimedon, Maria, 1985-; Barthelemy, Isabel; Zindel, Marc Y.; Sousa, Nuno; Barbero, José L.; Maldonado, Rafael, 1961-; Pérez Jurado, Luis Alberto; Campuzano Uceda, María Victoria (BioMed Central, 2010)
    Background: GTF2I codes for a general intrinsic transcription factor and calcium channel regulator TFII-I, with high and ubiquitous expression, and a strong candidate for involvement in the morphological and neuro-developmental ...
  • Aragón Manresa, Ferran; Pujades Corbi, Cristina (BioMed Central, 2009)
    Background: During early steps of embryonic development the hindbrain undergoes a regionalization process along the anterior-posterior (AP) axis that leads to a metameric organization in a series of rhombomeres (r). ...
  • Thomson, Timothy M.; Lozano, Juan José; Loukili, Noureddine; Carrió, Roberto; Serras Rigalt, Florenci; Cormand, Bru; Valeri, Marta; Díaz, Víctor M.; Abril Ferrando, Josep Francesc; Burset Albareda, Moisès; Merino, Jesús; Macaya, Alfons; Corominas Guiu, Montserrat; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press-CSHL Press, 2000)
    UEV proteins are enzymatically inactive variants of the E2 ubiquitin-conjugating enzymes that regulate noncanonical elongation of ubiquitin chains. In Saccharomyces cerevisiae, UEV is part of the RAD6-mediated error-free ...
  • Sansó Martínez, Miriam, 1979-; Vargas Pérez, Itzel; Quintales, Luis; Antequera, Francisco; Ayté del Olmo, José; Hidalgo Hernando, Elena (Oxford University Press, 2011)
    In the fission yeast, the MAP kinase Sty1 and the transcription factor Atf1 regulate up to 400 genes in response to environmental signals, and both proteins have been shown to bind to their promoters in a stress-dependent ...
  • Buxadé, Maria; Lunazzi, Giulia; Minguillón Pedreño, Jordi; Iborra, Salvador; Berga-Bolaños, Rosa; del Val, Margarita; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Rockefeller University Press, 2012)
    Toll-like receptors (TLRs) engage networks of transcriptional regulators to induce genes essential for antimicrobial immunity. We report that NFAT5, previously characterized as an osmostress responsive factor, regulates ...
  • Barneda Zahonero, Bruna; Román González, Lidia; Collazo, Olga; Rafati, Haleh; Islam, Abul, 1978-; Bussmann, Lars; Di Tullio, Alessandro, 1982-; Andrés, Luisa De; Graf, T. (Thomas); López Bigas, Núria; Mahmoudi, Tokameh; Parra, Maribel (Public Library of Science (PLoS), 2013)
    B lymphopoiesis is the result of several cell-commitment, lineage-choice, and differentiation processes. Every differentiation step is characterized by the activation of a new, lineage-specific, genetic program and the ...
  • Lyle, Robert; Prandini, Paola; Osoegawa, Kazutoyo; Ten Hallers, Boudewijn; Humphray, Sean; Zhu, Baoli; Eyras Jiménez, Eduardo; Castelo Valdueza, Robert; Bird, Christine P.; Gagos, Sarantos; Scott, Carol; Cox, Antony; Deutsch, Samuel; Ucla, Catherine; Cruts, Marc; Dahoun, Sophie; She, Xinwei; Bena, Frederique; Wang, Sheng-Yue; Broeckhoven, Christine van; Eichler, Evan E.; Guigó Serra, Roderic; Rogers, Jane; De Jong, Pieter J.; Reymond, Alexandre; Antonarakis, Stylianos E. (Cold Spring Harbor Laboratory Press-CSHL Press, 2007)
    The goals of the human genome project did not include sequencing of the heterochromatic regions. We describe here an initial sequence of 1.1 Mb of the short arm of human chromosome 21 (HSA21p), estimated to be 10% of 21p. ...
  • Orom, Ulf Andersson; Derrien, Thomas; Beringer, Malte; Gumireddy, Kiranmai; Gardini, Alessandro; Bussotti, Giovanni, 1983-; Lai, Fan; Zytnicki, Matthias; Notredame, Cedric; Huang, Qihong; Guigó Serra, Roderic; Shiekhattar, Ramin (Elsevier, 2010)
    While the long noncoding RNAs (ncRNAs) constitute a large portion of the mammalian transcriptome, their biological functions has remained elusive. A few long ncRNAs that have been studied in any detail silence gene expression ...
  • Truscott, Mary; Islam, Abul, 1978-; López Bigas, Núria; Frolov, Maxim V. (Cold Spring Harbor Laboratory Press (CSHL Press), 2011)
    The E2F family of transcription factors regulates the expression of both genes associated with cell proliferation and genes that regulate cell death. The net outcome is dependent on cellular context and tissue environment. ...
  • Blanco, Enrique; Guigó Serra, Roderic; Messeguer, Xavier (BioMed Central, 2007)
    Background: The analysis of the promoter sequence of genes with similar expression patterns is a basic tool to annotate common regulatory elements. Multiple sequence alignments are on the basis of most comparative ...
  • van der Valk, Ralf J.P.; Guxens, Mònica; Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium; Bustamante Pineda, Mariona; Estivill, Xavier, 1955-; González, Juan Ramón; Sunyer Deu, Jordi; Early Growth Genetics (EGG) Consortium (Oxford University Press, 2015)
    Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we ...
  • Denoeud, France; Kapranov, Philipp; Ucla, Catherine; Frankish, Adam; Castelo Valdueza, Robert; Drenkow, Jorg; Lagarde, Julien; Alioto, Tyler; Manzano, Caroline; Chrast, Jacqueline; Dike, Sujit; Wyss, Carine; Henrichsen, Charlotte N.; Holroyd, Nancy; Dickson, Mark C.; Taylor, Ruth; Hance, Zahra; Foissac, Sylvain; Myers, Richard M.; Rogers, Jane; Hubbard, Tim J.; Harrow, Jennifer; Guigó Serra, Roderic; Gingeras, Thomas R.; Antonarakis, Stylianos E.; Reymond, Alexandre (Cold Spring Harbor Laboratory Press-CSHL Press, 2007)
    This report presents systematic empirical annotation of transcript products from 399 annotated protein-coding loci across the 1% of the human genome targeted by the Encyclopedia of DNA elements (ENCODE) pilot project using ...
  • Zheng, Deyou; Frankish, Adam; Baertsch, Robert; Kapranov, Philipp; Reymond, Alexandre; Choo, Siew Woh; Lu, Yontao; Denoeud, France; Antonarakis, Stylianos E.; Snyder, Michael; Ruan, Yijun; Wei, Chia-Lin; Gingeras, Thomas R.; Guigó Serra, Roderic; Harrow, Jennifer; Gerstein, Mark B. (Cold Spring Harbor Laboratory Press-CSHL Press, 2007)
    Arising from either retrotransposition or genomic duplication of functional genes, pseudogenes are “genomic fossils” valuable for exploring the dynamics and evolution of genes and genomes. Pseudogene identification is an ...
  • Millanes Romero, Alba, 1986-; Herranz Martín, Nicolás; Perrera, Valentina; Iturbide, Ane; Loubat Casanovas, Jordina; Jenuwein, Thomas; García de Herreros, Antonio; Peiró Sales, Sandra (Elsevier, 2013)
    Although heterochromatin is enriched with repressive traits, it is also actively transcribed, giving rise to large amounts of noncoding RNAs. Although these RNAs are responsible for the formation and maintenance of ...
  • Al-Shahrour, Fátima; Minguez, Pablo; Marquès i Bonet, Tomàs, 1975-; Gazave, Elodie; Navarro i Cuartiellas, Arcadi, 1969-; Dopazo, Joaquín (Public Library of Science (PLoS), 2010)
    An increasing number of evidences show that genes are not distributed randomly across eukaryotic chromosomes, but rather in functional neighborhoods. Nevertheless, the driving force that originated and maintains such ...

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