Browsing Recerca: articles, congressos, llibres by Subject "Evolució molecular"

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Browsing Recerca: articles, congressos, llibres by Subject "Evolució molecular"

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  • Marquès i Bonet, Tomàs, 1975-; Kidd, Jeffrey M.; Ventura, Mario; Graves, Tina A.; Cheng, Ze; Hillier, LeDeana W.; Jiang, Zhaoshi; Baker, Carl; Malfavon-Borja, Ray; Fulton, Lucinda; Alkan, Can; Aksay, Gozde; Girirajan, Santhosh; Siswara, Priscillia; Chen, Lin; Cardone, Maria Francesca; Navarro i Cuartiellas, Arcadi, 1969-; Mardis, Elaine R.; Wilson, Richard K.; Eichler, Evan E. (Nature Publishing Group, 2009)
    It is generally accepted that the extent of phenotypic change between human and great apes is dissonant with the rate of molecular change. Between these two groups, proteins are virtually identical, cytogenetically there ...
  • Lorente-Galdós, Belén, 1981-; Bleyhl, Jonathan; Santpere, Gabriel; Vives, Laura; Ramírez, Oscar; Hernández Rodríguez, Jessica; Anglada Busquets, Roger; Cooper, Gregory M.; Navarro i Cuartiellas, Arcadi, 1969-; Eichler, Evan E.; Marquès i Bonet, Tomàs, 1975- (BioMed Central, 2013)
    BACKGROUND: The identification of signatures of natural selection has long been used as an approach to understanding the unique features of any given species. Genes within segmental duplications are overlooked in most ...
  • Mendizábal Eceizabarrena, Isabel, 1981-; Marigorta, Urko M.; Lao Grueso, Oscar, 1976-; Comas, David, 1969- (Springer, 2012)
    African Pygmies are hunter-gatherer populations from the equatorial rainforest that present the lowest height averages among humans. The biological basis and the putative adaptive role of the short stature of Pygmy populations ...
  • Sikora, Martin, 1976-; Laayouni, Hafid, 1968-; Calafell i Majó, Francesc; Comas, David, 1969-; Bertranpetit, Jaume, 1952- (Nature Publishing Group, 2011)
    Studies of large sets of SNP data have proven to be a powerful tool in the analysis of the genetic structure of human populations. In this work, we analyze genotyping data for 2,841 SNPs in 12 Sub-Saharan African populations, ...
  • Ramírez, Oscar; Olalde, Iñigo; Berglund, Jonas; Lorente-Galdós, Belén, 1981-; Hernández Rodríguez, Jessica; Quilez, Javier; Webster, Matthew T; Wayne, Robert K.; Lalueza Fox, Carles, 1965-; Vilà, Carles; Marquès i Bonet, Tomàs, 1975- (BioMed Central, 2014)
    Background: Although a variety of genetic changes have been implicated in causing phenotypic differences among dogs, the role of copy number variants (CNVs) and their impact on phenotypic variation is still poorly understood. ...
  • Worley, Kim C.; Lorente-Galdós, Belén, 1981-; Marquès i Bonet, Tomàs, 1975-; Wilson, Richard K.; The Marmoset Genome Sequencing and Analysis Consortium (Nature Publishing Group, 2014)
    We report the whole-genome sequence of the common marmoset (Callithrix jacchus). The 2.26-Gb genome of a female marmoset was assembled using Sanger read data (6×) and a whole-genome shotgun strategy. A first analysis has ...
  • Bekpen, Cemalettin; Marquès i Bonet, Tomàs, 1975-; Alkan, Can; Antonacci, Francesca; Leogrande, Maria Bruna; Ventura, Mario; Kidd, Jeffrey M.; Siswara, Priscillia; Howard, Jonathan C.; Eichler, Evan E. (Public Library of Science (PLoS), 2009)
    Immunity-related GTPases (IRG) play an important role in defense against intracellular pathogens. One member of this gene family in humans, IRGM, has been recently implicated as a risk factor for Crohn's disease. We analyzed ...
  • Jiménez, Alba; Cotterell, James; Munteanu, Andreea; Sharpe, James (Cold Spring Harbor Laboratory Press, 2015)
    To what extent does the dynamical mechanism producing a specific biological phenotype bias the ability to evolve into novel phenotypes? We use the interpretation of a morphogen gradient into a single stripe of gene expression ...
  • Widder, Stefanie; Solé Vicente, Ricard, 1962-; Macía, Javier (BioMed Central, 2012)
    Background: Transcription networks define the core of the regulatory machinery of cellular life and are largely responsible for information processing and decision making. At the small scale, interaction motifs have been ...
  • Martinez, Javier P; Bocharov, Gennady A.; Ignatovich, Anna; Reiter, Jochen; Dittmar, Matthias T; Wain-Hobson, Simon; Meyerhans, Andreas (Public Library of Science (PLoS), 2011)
    Fitness interactions between mutations, referred to as epistasis, can strongly impact evolution. For RNA viruses and retroviruses with their high mutation rates, epistasis may be particularly important to overcome fitness ...
  • Freedman, Adam H; Lorente-Galdós, Belén, 1981-; Ramírez, Oscar; Marquès i Bonet, Tomàs, 1975-; Novembre, John (Public Library of Science (PLoS), 2014)
    To identify genetic changes underlying dog domestication and reconstruct their early evolutionary history, we generated high-quality genome sequences from three gray wolves, one from each of the three putative centers of ...
  • Moreno Estrada, Andrés; Bosch Fusté, Elena; Stoneking, Mark; Bertranpetit, Jaume, 1952-; Calafell i Majó, Francesc; Navarro i Cuartiellas, Arcadi, 1969-; Casals López, Ferran; Tang, Kun; Marquès i Bonet, Tomàs, 1975-; Sikora, Martin, 1976- (Oxford University Press, 2009)
    Different signatures of natural selection persist over varying time scales in our genome, revealing possible episodes of adaptative evolution during human history. Here, we identify genes showing signatures of ancestral ...
  • Taskov, Kalin; Chapple, Charles E.; Kryukov, Gregory V.; Castellano Hereza, Sergi; Lobanov, Alexei V.; Korotkov, Konstantin V.; Guigó Serra, Roderic; Gladyshev, Vadim N. (Oxford University Press, 2005)
    Selenocysteine (Sec) is co-translationally inserted into selenoproteins in response to codon UGA with the help of the selenocysteine insertion sequence (SECIS) element. The number of selenoproteins in animals varies, with ...
  • Arkhipova, Oksana V.; Meer, Margarita V.; Mikoulinskaia, Galina V.; Zakharova, Marina V.; Galushko, Alexander S.; Akimenko, Vasilii K.; Kondrashov, Fyodor (Public Library of Science (PLoS), 2015)
    The origin and evolution of novel biochemical functions remains one of the key questions in molecular evolution. We study recently emerged methacrylate reductase function that is thought to have emerged in the last century ...
  • Hernando Herráez, Irene; Heyn, Holger; Fernández Callejo, Marcos; Vidal, Enrique; Fernandez Bellon, Hugo; Prado Martínez, Javier, 1987-; Sharp, Andrew J.; Esteller, Manel; Marquès i Bonet, Tomàs, 1975- (Oxford University Press, 2015)
    Despite the increasing knowledge about DNA methylation, the understanding of human epigenome evolution is in its infancy. Using whole genome bisulfite sequencing we identified hundreds of differentially methylated regions ...
  • Marquès i Bonet, Tomàs, 1975-; Girirajan, Santhosh; Eichler, Evan E. (Elsevier, 2009)
    Duplicated sequences are substrates for the emergence of new genes and are an important source of genetic instability associated with rare and common diseases. Analyses of primate genomes have shown an increase in the ...
  • Gayà Vidal, Magdalena; Albà Soler, Mar (BioMed Central, 2014)
    Background: The recent increase in human polymorphism data, together with the availability of genome sequences from several primate species, provides an unprecedented opportunity to investigate how natural selection has ...
  • Erb, Ionas; González-Vallinas Rostes, Juan, 1983-; Bussotti, Giovanni, 1983-; Blanco, Enrique; Eyras Jiménez, Eduardo; Notredame, Cedric (Oxford University Press, 2012)
    We address the challenge of regulatory sequence alignment with a new method, Pro-Coffee, a multiple aligner specifically designed for homologous promoter regions. Pro-Coffee uses a dinucleotide substitution matrix estimated ...

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