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Visualitza Recerca: articles, congressos, llibres per autoria "Esteller, Manel"

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A DNA methylation map of human cancer at single base-pair resolution

Vidal Ocabo, Enrique; Sayols, Sergi; Moran, Sebastian; Guillaumet-Adkins, Amy; Schroeder, Michael Philipp, 1986-; Royo, Romina; Orozco, Modesto; Gut, Marta; Gut, Ivo Glynne; López Bigas, Núria; Heyn, Holger; Esteller, Manel (Nature Publishing Group, 2017)

Although single base-pair resolution DNA methylation landscapes for embryonic and different somatic cell types provided important insights into epigenetic dynamics and cell-type specificity, such comprehensive profiling ...
A Landscape of Pharmacogenomic Interactions in Cancer.

Iorio, Francesco Iorio; Tamborero Noguera, David; López Bigas, Núria; Esteller, Manel; Garnett, Mathew J. (Elsevier, 2016)

Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature of cancer. Using this information to guide the development and application of therapies in the clinic is challenging. Here, ...
Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study

Cullell, Natalia; Soriano Tarraga, Carolina; Gallego-Fabrega, Cristina; Cárcel-Márquez, Jara; Muiño, Elena; Llucià-Carol, Laia; Lledós, Miquel; Esteller, Manel; Castro de Moura, Manuel; Montaner, Joan; Rosell, Anna; Delgado, Pilar; Martí-Fàbregas, Joan; Krupinski, Jerzy; Roquer, Jaume; Jiménez Conde, Jordi; Fernández-Cadenas, Israel (BioMed Central, 2022)

Background and purpose: the neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play ...
APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals

Cacciaglia, Raffaele; Molinuevo, José Luis; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt Fombuena, Nina; Brugulat Serrat, Anna, 1986-; Esteller, Manel; Morán, Sebastián; Fauria, Karine; Gispert López, Juan Domingo; ALFA Study (Elsevier, 2019)

The APOE-ε4 genotype is the highest genetic risk factor for Alzheimer's disease (AD). In cognitively unimpaired individuals, it has been related to altered brain morphology, function and earlier amyloid beta accumulation. ...
The B cell transcription program mediates hypomethylation and overexpression of key genes in Epstein-Barr virus-associated proliferative conversion

Hernando, Henar; Shannon Lowe, Claire; Islam, Abul, 1978-; Al-Shahrour, Fátima; Rodríguez Ubreva, Javier; Rodríguez Cortez, Virginia C; Javierre, Biola M.; Mangas, Cristina; Fernández, Agustín F.; Parra, Maribel; Delecluse, Henri Jacques; Esteller, Manel; López Granados, Eduardo; Fraga, Mario F.; López Bigas, Núria; Ballestar, Esteban (BioMed Central, 2013)

Background: Epstein-Barr virus (EBV) infection is a well characterized etiopathogenic factor for a variety of immune-related conditions, including lymphomas, lymphoproliferative disorders and autoimmune diseases. EBV-mediated ...
B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation

Bueno-Costa, Alberto; Piñeyro, David; Soler, Marta; Javierre, Biola M.; Raurell Vila, Helena; Subirana-Granés, Marc; Pasquali, Lorenzo; Martinez-Climent, Jose A.; Esteller, Manel (Nature Research, 2020)
Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors

Martin-Trujillo, Alex; Vidal Ocabo, Enrique; Monteagudo-Sánchez, Ana; Sanchez-Delgado, Marta; Moran, Sebastian; Hernández Mora, José Ramón; Heyn, Holger; Guitart, Miriam; Esteller, Manel; Monk, David (Nature Publishing Group, 2017)

It has been postulated that imprinting aberrations are common in tumors. To understand the role of imprinting in cancer, we have characterized copy-number and methylation in over 280 cancer cell lines and confirm our ...
DNA methylation biomarkers of myocardial infarction and cardiovascular disease

Fernández Sanlés, Alba, 1988-; Sayols Baixeras, Sergi, 1988-; Subirana Cachinero, Isaac; Sentí Clapés, Mariano; Pérez-Fernández, Silvia; Castro de Moura, Manuel; Esteller, Manel; Marrugat de la Iglesia, Jaume; Elosua Llanos, Roberto (BioMed Central, 2021)

Background: The epigenetic landscape underlying cardiovascular disease (CVD) is not completely understood and the clinical value of the identified biomarkers is still limited. We aimed to identify differentially methylated ...
DNA methylation contributes to natural human variation

Heyn, Holger; Moran, Sebastian; Hernando Herráez, Irene, 1985-; Sayols, Sergi; Gómez, Antonio; Sandoval, Juan; Monk, Dave; Hata, Kenichiro; Marquès i Bonet, Tomàs, 1975-; Wang, Liewei; Esteller, Manel (Cold Spring Harbor Laboratory Press (CSHL Press), 2013)

DNA methylation patterns are important for establishing cell, tissue, and organism phenotypes, but little is known about their contribution to natural human variation. To determine their contribution to variability, we ...
A DNA methylation fingerprint of 1628 human samples

Pérez Jurado, Luis Alberto; Fernández, Agustín F.; Esteller, Manel (Cold Spring Harbor Laboratory Press (CSHL Press), 2012)

Most of the studies characterizing DNA methylation patterns have been restricted to particular genomic loci in a limited number of human samples and pathological conditions. Herein, we present a compromise between an ...
DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues

Gallego-Fabrega, Cristina; Cullell, Natalia; Soriano Tarraga, Carolina; Carrera, Caty; Torres-Aguila, Nuria P.; Muiño, Elena; Cárcel-Márquez, Jara; Castro de Moura, Manuel; Fernández Sanlés, Alba, 1988-; Esteller, Manel; Elosua Llanos, Roberto; Jiménez Conde, Jordi; Roquer, Jaume; Montaner, Joan; Krupinski, Jerzy; Fernández-Cadenas, Israel (Impact Journals, 2020)

Background and purpose: Polymorphisms and serum levels of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) have been studied with regard to atheromatous plaques and ischemic stroke, while ...
Dynamics of DNA methylation in recent human and great ape evolution

Hernando Herráez, Irene, 1985-; Prado Martínez, Javier, 1987-; Garg, Paras; Fernández Callejo, Marcos; Heyn, Holger; Hvilsom, Christina; Navarro i Cuartiellas, Arcadi, 1969-; Esteller, Manel; Sharp, Andrew J.; Marquès i Bonet, Tomàs, 1975- (Public Library of Science (PLoS), 2013)

DNA methylation is an epigenetic modification involved in regulatory processes such as cell differentiation during development, X-chromosome inactivation, genomic imprinting and susceptibility to complex disease. However, ...
Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study

Vilor Tejedor, Natàlia, 1988-; Operto, Grégory; Evans, Tavia E.; Falcón, Carles; Crous-Bou, Marta; Minguillón, Carolina; Cacciaglia, Raffaele; Milà Alomà, Marta; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Garrido Martín, Diego, 1992-; Morán, Sebastián; Esteller, Manel; Adams, Hieab H.; Molinuevo, José Luis; Guigó Serra, Roderic; Gispert López, Juan Domingo; ALFA Study (Springer, 2020)

Background: Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous studies on the association ...
Epigenetic loss of the endoplasmic reticulum-associated degradation inhibitor SVIP induces cancer cell metabolic reprogramming

Llinàs Arias, Pere; Moutinho, Catia; Esteller, Manel (American Society for Clinical Investigation, 2019)

The endoplasmic reticulum (ER) of cancer cells needs to adapt to the enhanced proteotoxic stress associated with the accumulation of unfolded, misfolded and transformation-associated proteins. One way by which tumors thrive ...
Epigenome-wide association study of COVID-19 severity with respiratory failure

Castro de Moura, Manuel; Villar García, Judit; Horcajada Gallego, Juan Pablo; Esteller, Manel (Elsevier, 2021)

Background: Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide spectrum of disease behaviour. Since DNA methylation ...
Genetic characterization of the ALFA study: Uncovering genetic profiles in the Alzheimer's continuum

Vilor Tejedor, Natàlia, 1988-; Genius, Patricia; Rodríguez-Fernández, Blanca; Minguillón, Carolina; Sadeghi, Iman; González-Escalante, Armand; Crous-Bou, Marta; Suárez-Calvet, Marc; Grau-Rivera, Oriol; Brugulat Serrat, Anna, 1986-; Sánchez Benavides, Gonzalo; Esteller, Manel; Fauria, Karine; Molinuevo, José Luis; Navarro i Cuartiellas, Arcadi, 1969-; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative; ALFA Study (Wiley, 2023)

Introduction: In 2013, the ALzheimer's and FAmilies (ALFA) project was established to investigate pathophysiological changes in preclinical Alzheimer's disease (AD), and to foster research on early detection and preventive ...
Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region

Ciampa, Iacopo; Operto, Grégory; Falcón, Carles; Minguillón, Carolina; Castro de Moura, Manuel; Piñeyro, David; Esteller, Manel; Molinuevo, José Luis; Guigó Serra, Roderic; Navarro i Cuartiellas, Arcadi, 1969-; Gispert López, Juan Domingo; Vilor Tejedor, Natàlia, 1988-; ALFA Study (MDPI, 2021)

This study investigated whether genetic factors involved in Alzheimer's disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and ...
Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study

Moore, Lee E.; Pfeiffer, Ruth M.; Poscablo, Cristina; Real, Francisco X.; Kogevinas, Manolis; Silverman, Debra T.; García Closas, Reina; Chanock, Stephen J.; Tardón, Adonina; Serra, Consol; Carrato, Alfredo; Dosemeci, Mustafa; García Closas, Montserrat; Esteller, Manel; Fraga, Mario F.; Rothman, Nathaniel; Malats i Riera, Núria (Elsevier, 2008)

BACKGROUND: DNA hypomethylation has been suggested to cause genomic instability and increase cancer risk. We aimed to test the hypothesis that DNA hypomethylation is associated with increased risk of bladder cancer. METHODS: ...
Histone H1 depletion triggers an interferon response in cancer cells via activation of heterochromatic repeats

Izquierdo Bouldstridge, Andrea; Bustillos, Alberto; Bonet-Costa, Carles; Aribau-Miralbés, Patricia; García-Gomis, Daniel; Dabad, Marc; Esteve-Codina, Anna; Pascual-Reguant, Laura, 1990-; Peiró Sales, Sandra; Esteller, Manel; Murtha, Matthew; Millán Ariño, Lluís, 1984-; Jordan Vallès, Albert (Oxford University Press, 2017)

Histone H1 has seven variants in human somatic cells and contributes to chromatin compaction and transcriptional regulation. Knock-down (KD) of each H1 variant in breast cancer cells results in altered gene expression and ...
Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns

Sánchez Mut, Jose V.; Heyn, Holger; Vidal, Enrique; Moran, Sebastian; Sayols, Sergi; Delgado Morales, Raul; Schultz, Matthew D.; Ansoleaga, Belén; García Esparcia, Paula; Pons Espinal, Meritxell, 1986-; Martínez de Lagran, Maía; Dopazo, Jose M.; Rábano, Alberto; Ávila, Jesús; Dierssen, Mara; Lott, Ira T.; Ferrer, Isidre; Ecker, Joseph R.; Esteller, Manel (Nature Publishing Group, 2016)

Different neurodegenerative disorders often show similar lesions, such as the presence of amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited forms are rare, so we wondered whether shared ...