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  • A Sense of Balance: Experimental Investigation and Modeling of a Malonyl-CoA Sensor in Escherichia coli
    Fehér, Tamás; Libis, Vincent; Carbonell, Pablo; Faulon, Jean-Loup (Frontiers, 2015)
    Production of value-added chemicals in microorganisms is regarded as a viable alternative to chemical synthesis. In the past decade, several engineered pathways producing such chemicals, including plant secondary metabolites ...
  • A set of accessible enhancers enables the initial response of breast cancer cells to physiological progestin concentrations
    Zaurín Quer, Roser; Ferrari, Roberto; Nacht, A. Silvina; Carbonell-Caballero, Jose; Le Dily, François; Font Mateu, Jofre, 1977-; De Llobet, Lara Isabel; Vidal Ocabo, Enrique; Lioutas, Antonio, 1980-; Beato, Miguel; Vincent, Guillermo P. (Oxford University Press, 2021)
    Here, we report that in T47D breast cancer cells 50 pM progestin is sufficient to activate cell cycle entry and the progesterone gene expression program. At this concentration, equivalent to the progesterone blood levels ...
  • A set of systematic reviews to help reduce inappropriate prescribing to older people: study protocol
    Martinez, Yolanda V.; Renom-Guiteras, Anna; Reeves, David; Erandie Ediriweera de Silva, R.; Esmail, Aneez; Kunnamo, Ilkka; Rieckert, Anja; Sommerauer, Christina; Sönnichsen, Andreas (BioMed Central, 2017)
    BACKGROUND: Multimorbidity and polypharmacy are common in older people. Assessment tools or lists of criteria aimed at supporting prescription decisions for older people exist, but have often been based on expert opinion ...
  • A set point in the selection of the αβTCR T cell repertoire imposed by pre-TCR signaling strength
    Bovolenta, Elena R.; García-Cuesta, Eva M.; Horndler, Lydia; Ponomarenko, Julia; Schamel, Wolfgang W.; Mellado, Mario; Castro, Mario; Abia, David; van Santen, Hisse M. (National Academy of Sciences, 2022)
    Signaling via the T cell receptor (TCR) is critical during the development, maintenance, and activation of T cells. Quantitative aspects of TCR signaling have an important role during positive and negative selection, lineage ...
  • A shift in anterior–posterior positional information underlies the fin-to-limb evolution
    Onimaru, Koh; Kuraku, Shigehiro; Takagi, Wataru; Hyodo, Susumu; Sharpe, James; Tanaka, Mikiko (eLife, 2015)
    The pectoral fins of ancestral fishes had multiple proximal elements connected to their pectoral girdles. During the fin-to-limb transition, anterior proximal elements were lost and only the most posterior one remained as ...
  • A short motif in Drosophila SECIS Binding Protein 2 provides differential binding affinity to SECIS RNA hairpins
    Takeuchi, Akiko; Schmitt, David; Chapple, Charles E.; Babaylova, Elena; Karpova, Galina; Guigó Serra, Roderic; Krol, Alain; Allmang, Christine (Oxford University Press, 2009)
    Selenoproteins contain the amino acid selenocysteine which is encoded by a UGA Sec codon. Recoding UGA Sec requires a complex mechanism, comprising the cis-acting SECIS RNA hairpin in the 3′UTR of selenoprotein mRNAs, and ...
  • A signature of attractor dynamics in the CA3 region of the hippocampus
    Rennó Costa, César; Lisman, John E.; Verschure, Paul F. M. J. (Public Library of Science, 2014)
    The notion of attractor networks is the leading hypothesis for how associative memories are stored and recalled. A defining/nanatomical feature of such networks is excitatory recurrent connections. These ‘‘attract’’ the ...
  • A Simple fusion of deep and shallow learning for acoustic scene classification
    Fonseca, Eduardo; Gong, Rong; Serra, Xavier (Cyprus University of Technology, 2018)
    In the past, Acoustic Scene Classification systems havebeen based on hand crafting audio features that are input toa classifier. Nowadays, the common trend is to adopt datadriven techniques, e.g., deep learning, where audio ...
  • A simple microfluidic platform to study age-dependent protein abundance and localization changes in Saccharomyces cerevisiae
    Cabrera, Margarita; Novarina, Daniele; Rempel, Irina L.; Veenhoff, Liesbeth M.; Chang, Michael (Shared Science Publishers, 2017)
    The budding yeast Saccharomyces cerevisiae divides asymmetrically, with a smaller daughter cell emerging from its larger mother cell. While the daughter lineage is immortal, mother cells age with each cell division and ...
  • A simple score to identify super-responders to sacubitril/valsartan in ambulatory patients with heart failure
    Moliner Abós, Carles; Mojón Álvarez, Diana; Rivas-Lasarte, Mercedes; Belarte Tornero, Laia Carla; Pamies Besora, Julia; Solé-González, Eduard; Fluvià Brugues, Paula; Zegrí Reiriz, Isabel; López-López, Laura; Brossa, Vicens; Pirla, María J.; Mesado, Nuria; Mirabet, Sonia; Roig, Eulàlia; Álvarez-García, Jesus (Frontiers, 2021)
    Introduction: Sacubitril/valsartan (SV) promotes cardiac remodeling and improves prognosis in patients with heart failure (HF). However, the response to the drug may vary between patients and its implementation in daily ...
  • A Single Amino Acid Deletion (ΔF1502) in the S6 Segment of CaV2.1 Domain III Associated with Congenital Ataxia Increases Channel Activity and Promotes Ca2+ Influx
    Bahamonde Santos, María Isabel, 1972-; Serra Pascual, Selma A., 1981-; Drechsel, Oliver; Rahman, Rubayte; Marcé-Grau, Anna; Prieto, Marta; Ossowski, Stephan; Macaya, Alfons; Fernández-Fernández, José Manuel, 1967- (Public Library of Science (PLoS), 2015)
    Mutations in the CACNA1A gene, encoding the pore-forming CaV2.1 (P/Q-type) channel α1A subunit, result in heterogeneous human neurological disorders, including familial and sporadic hemiplegic migraine along with episodic ...
  • A single dose of dendrimer B2T peptide vaccine partially protects pigs against foot-and-mouth disease virus infection
    Cañas Arranz, Rodrigo; Forner, Mar, 1980-; Defaus, Sira; de León, Patricia; Bustos, María J.; Torres, Elisa; Sobrino, Francisco; Andreu Martínez, David; Blanco, Esther (MDPI, 2020)
    Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hoofed animals whose control relies on efficient vaccination. We have reported that dendrimer peptide B2T, with two copies of FMDV B-cell ...
  • A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background
    García Closas, Montserrat; Hein, David W.; Silverman, Debra T.; Malats i Riera, Núria; Yeager, Meredith; Jacobs, Kevin; Doll, Mark A.; Figueroa, Jonine D.; Baris, Dalsu; Schwenn, Molly; Kogevinas, Manolis; Johnson, Alison; Chatterjee, Nilanjan; Moore, Lee E.; Moeller, Timothy; Real, Francisco X.; Chanock, Stephen J.; Rothman, Nathaniel (Lippincott Williams & Wilkins, 2011)
    The arylamine N-acetyltransferase 2 (NAT2) slow acetylation phenotype is an established risk factor for urinary bladder cancer. We reported earlier on this risk association using NAT2 phenotypic categories inferred from ...
  • A single-cell tumor immune atlas for precision oncology
    Nieto, Paula; Elosua-Bayés, Marc; Trincado Alonso, Juan Luis, 1987-; Marchese, Domenica, 1986-; Massoni-Badosa, Ramon; Nieto, Juan C.; Aguilar-Fernández, Sergio; Mereu, Elisabetta; Moutinho, Catia; Ruiz, Sara; Lorden, Patricia; Gut, Ivo Glynne; Heyn, Holger (Cold Spring Harbor Laboratory Press (CSHL Press), 2021)
    The tumor immune microenvironment is a main contributor to cancer progression and a promising therapeutic target for oncology. However, immune microenvironments vary profoundly between patients, and biomarkers for prognosis ...
  • A single-cell view on alga-virus interactions reveals sequential transcriptional programs and infection states
    Ku, Chuan; Sheyn, Uri; Sebé-Pedrós, Arnau; Ben-Dor, Shifra; Schatz, Daniella; Tanay, Amos; Rosenwasser, Shilo; Vardi, Assaf (American Association for the Advancement of Science (AAAS), 2020)
    The discovery of giant viruses infecting eukaryotes from diverse ecosystems has revolutionized our understanding of the evolution of viruses and their impact on protist biology, yet knowledge on their replication strategies ...
  • A single-letter upper bound to the mismatch capacity
    Kangarshahi, Ehsan Asadi; Guillén i Fábregas, A. (Albert) (Institute of Electrical and Electronics Engineers (IEEE), 2021)
    We derive a single-letter upper bound to the mismatched-decoding capacity for discrete memoryless channels. The bound is expressed as the mutual information of a transformation of the channel, such that a maximum-likelihood ...
  • A six-attribute classification of genetic mosaicism
    Martínez-Glez, Víctor; Tenorio Castaño, Jair; Nevado, Julián; Gordo, Gema; Rodríguez-Laguna, Lara; Feito, Marta; Lucas, Raúl de; Pérez Jurado, Luis Alberto; Ruiz Pérez, Víctor L.; Torrelo, Antonio; Spinner, Nancy B.; Happle, Rudolf; Biesecker, Leslie G.; Lapunzina, Pablo Daniel (Nature Research, 2020)
    Mosaicism denotes an individual who has at least two populations of cells with distinct genotypes that are derived from a single fertilized egg. Genetic variation among the cell lines can involve whole chromosomes, structural ...
  • A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition
    Vincent, Theresa; Neve, Etienne P.A.; Johnson, Jill R.; Kukalev, Alexander; Rojo, Federico; Albanell Mestres, Joan; Pietras, Kristian; Virtanen, Ismo; Philipson, Lennart; Leopold, Philip L.; Crystal, Ronald G.; García de Herreros, Antonio; Moustakas, Aristidis; Petterson, Ralf F.; Fuxe, Jonas (Nature Research, 2009)
    Epithelial-mesenchymal transition (EMT) is essential for organogenesis and is triggered during carcinoma progression to an invasive state. Transforming growth factor-beta (TGF-beta) cooperates with signalling pathways, ...
  • A social companion and conversation partner for elderly
    Miehle, Juliana; Bagci, Ilker; Minker, Wolfgang; Ultes, Stefan (Springer, 2017)
    In this work, we present the development and evaluation of a social companion and conversation partner for the special user group of elderly.With the aim of designing a user-adaptive system, we responded to the desires of ...
  • A Social learning space grid for MOOCs: exploring a FutureLearn case
    Manathunga, Kalpani; Hernández Leo, Davinia; Sharples, Mike (Springer, 2017)
    Collaborative and social engagement promote active learning through knowledge intensive interactions. Massive Open Online Courses (MOOCs) are dynamic and diversified learning spaces with varying factors like flexible time ...

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