AlthoughH1- antihistaminescurrentlyconstitutethelargestclassofmedicationsusedinthetreatmentofallergicdisorders,somecasesofhypersensitivityreactionsduetovariousantihistaminepreparations,suchasfixeddrugeruptions,contactdermatitis,maculo- papularrash,andurticarialreactions,havebeenreported(1).Wereporthereintwopatientswithchronicspontaneousurticaria(CSU)inwhichantihistaminesactedasexacerbatingfactorsofthediseaseandrequiredanalternativetreatment.Theunderlyingmechanismintheseparticularcasesisnotentir ...
AlthoughH1- antihistaminescurrentlyconstitutethelargestclassofmedicationsusedinthetreatmentofallergicdisorders,somecasesofhypersensitivityreactionsduetovariousantihistaminepreparations,suchasfixeddrugeruptions,contactdermatitis,maculo- papularrash,andurticarialreactions,havebeenreported(1).Wereporthereintwopatientswithchronicspontaneousurticaria(CSU)inwhichantihistaminesactedasexacerbatingfactorsofthediseaseandrequiredanalternativetreatment.Theunderlyingmechanismintheseparticularcasesisnotentirelyclear,butatype-I(immediate)hypersensitivityreactionshouldbeconsidered
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