Sir2 plays a key role in cell fate determination upon SAPK activation

Vendrell Arasa, Alexandre; Posas Garriga, Francesc

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dc.contributor.author	Vendrell Arasa, Alexandre
dc.contributor.author	Posas Garriga, Francesc
dc.date.accessioned	2015-05-25T07:13:20Z
dc.date.available	2015-05-25T07:13:20Z
dc.date.issued	2011
dc.identifier.citation	Vendrell A, Posas F. Sir2 plays a key role in cell fate determination upon SAPK activation. Aging. 2011; 3(12): 1163-1168. DOI: 10.18632/aging.100419
dc.identifier.issn	1945-4589
dc.identifier.uri	http://hdl.handle.net/10230/23633
dc.description.abstract	Although the benefit of sirtuin activation in age-related diseases is well-characterized, the benefit of sirtuin activation in acute diseases has been elusive. Here we discuss that, at least in yeast, Sir2 activation prevents programmed cell death induced by the sustained activation of the stress activated protein kinase (SAPK) Hog1, the yeast homologue of the p38 SAPK. Sir2 prevents ROS formation and maximize cell survival upon SAPK activation. The conserved function of Sir2 in age-related diseases and the conserved role of SAPKs open the possibility of a novel role for sirtuins in cell fate determination in eukaryotic cells.
dc.description.sponsorship	We thank to EdeN for constant support. The laboratory of FP and EdeN is supported by grants from the Ministerio de Ciéncia y Innovación, the Consolider Ingenio 2010 programme and FP7 UNICELLSYS grant to F.P, EdeN. F.P. is also supported by the Fundación Marcelino Botín (FMB) and ICREA Acadèmia (Generalitat de Catalunya)
dc.format.mimetype	application/pdf
dc.language.iso	eng
dc.publisher	Impact Journals
dc.relation.ispartof	Aging. 2011;3(12):1163-8
dc.rights	© Vendrell and Posas. This is an open‐access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.rights.uri	https://creativecommons.org/licenses/by/3.0/
dc.subject.other	Apoptosi
dc.subject.other	Proteïnes quinases -- Metabolisme
dc.subject.other	Regulació cel·lular
dc.subject.other	Envelliment
dc.title	Sir2 plays a key role in cell fate determination upon SAPK activation
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	http://dx.doi.org/10.18632/aging.100419
dc.relation.projectID	info:eu-repo/grantAgreement/EC/FP7/201142
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.type.version	info:eu-repo/semantics/publishedVersion