Mostra el registre parcial de l'element
dc.contributor.author | Agostini, Federico, 1985- |
dc.contributor.author | Cirillo, Davide |
dc.contributor.author | Bolognesi, Benedetta |
dc.contributor.author | Tartaglia, Gian Gaetano |
dc.date.accessioned | 2014-06-03T07:23:31Z |
dc.date.available | 2014-06-03T07:23:31Z |
dc.date.issued | 2013 |
dc.identifier.citation | Agostini F, Cirillo D, Bolognesi B, Tartaglia GG. X-inactivation: quantitative predictions of protein interactions in the Xist network. Nucleic Acids Res. 2013; 41(1): e31. DOI: 10.1093/nar/gks968 |
dc.identifier.issn | 0305-1048 |
dc.identifier.uri | http://hdl.handle.net/10230/22553 |
dc.description.abstract | The transcriptional silencing of one of the female X-chromosomes is a finely regulated process that requires accumulation in cis of the long non-coding RNA X-inactive-specific transcript (Xist) followed by a series of epigenetic modifications. Little is known about the molecular machinery regulating initiation and maintenance of chromosomal silencing. Here, we introduce a new version of our algorithm catRAPID to investigate Xist associations with a number of proteins involved in epigenetic regulation, nuclear scaffolding, transcription and splicing processes. Our method correctly identifies binding regions and affinities of protein interactions, providing a powerful theoretical framework for the study of X-chromosome inactivation and other events mediated by ribonucleoprotein associations. |
dc.description.sponsorship | Funding for open access charge: Spanish Ministry of Economy and Competitiveness [SAF2011-26211] |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | Oxford University Press |
dc.relation.ispartof | Nucleic Acids Research. 2013;41(1):e31 |
dc.rights | © 2013 Federico Agostini et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of a Creative Commons Attribution License |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/ |
dc.subject.other | Algoritmes |
dc.subject.other | Cromosoma X |
dc.subject.other | RNA |
dc.title | X-inactivation: quantitative predictions of protein interactions in the Xist network |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.1093/nar/gks968 |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/3PN/SAF2011-26211 |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/publishedVersion |