Toward integrated management of cerebral aneurysms

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Villa-Uriol M C, Larrabide I, Pozo J M, Kim M, Camara O, De Craene M, Zhang C, Geers A J, Morales H, Bogunovic H, Cardenes R, Frangi A F. Toward integrated management of cerebral aneurysms. Philos Transact A Math Phys Eng Sci. 2010; 368(1921): 2961-2982. DOI: 10.1098/rsta.2010.0095
http://hdl.handle.net/10230/16686
To cite or link this document: http://hdl.handle.net/10230/16686
dc.contributor.author Villa-Uriol, Maria-Cruz
dc.contributor.author Larrabide, Ignacio
dc.contributor.author Pozo Soler, José Ma. (José María)
dc.contributor.author Kim, Minsuok
dc.contributor.author Camara, Oscar
dc.contributor.author De Craene, Mathieu
dc.contributor.author Zhang, Chong
dc.contributor.author Geers, Arjan
dc.contributor.author Morales, Hernán
dc.contributor.author Bogunovic, Hrvoje
dc.contributor.author Cardenes, R.
dc.contributor.author Frangi Caregnato, Alejandro
dc.contributor.other Universitat Pompeu Fabra
dc.date.accessioned 2012-07-09T09:58:43Z
dc.date.available 2012-07-09T09:58:43Z
dc.date.issued 2010
dc.identifier.citation Villa-Uriol M C, Larrabide I, Pozo J M, Kim M, Camara O, De Craene M, Zhang C, Geers A J, Morales H, Bogunovic H, Cardenes R, Frangi A F. Toward integrated management of cerebral aneurysms. Philos Transact A Math Phys Eng Sci. 2010; 368(1921): 2961-2982. DOI: 10.1098/rsta.2010.0095
dc.identifier.issn 1364-503X
dc.identifier.uri http://hdl.handle.net/10230/16686
dc.description.abstract In the last few years, some of the visionary concepts behind the virtual physiological human began to be demonstrated on various clinical domains, showing great promise for improving healthcare management. In the current work, we provide an overview of image- and biomechanics-based techniques that, when put together, provide a patient-specific pipeline for the management of intracranial aneurysms. The derivation and subsequent integration of morphological, morphodynamic, haemodynamic and structural analyses allow us to extract patient-specific models and information from which diagnostic and prognostic descriptors can be obtained. Linking such new indices with relevant clinical events should bring new insights into the processes behind aneurysm genesis, growth and rupture. The development of techniques for modelling endovascular devices such as stents and coils allows the evaluation of alternative treatment scenarios before the intervention takes place and could also contribute to the understanding and improved design of more effective devices. A key element to facilitate the clinical take-up of all these developments is their comprehensive validation. Although a number of previously published results have shown the accuracy and robustness of individual components, further efforts should be directed to demonstrate the diagnostic and prognostic efficacy of these advanced tools through large-scale clinical trials.
dc.description.sponsorship This work was partially supported by the @neurIST Integrated Project (co-financed by the European Commission through contract no. IST-027703), a CDTI CENIT-CDTEAM grant funded by the Spanish Ministry of Science and Innovation (MICINN-CDTI) and Philips Healthcare (Best, The Netherlands). The authors are also grateful for the support provided by ANSYS Inc. (Canonsburg, PA, USA).
dc.language.iso eng
dc.publisher Royal Society
dc.relation.ispartof Philos Transact A Math Phys Eng Sci. 2010; 368(1921): 2961-2982
dc.rights © 2010, The Royal Society. The definitive published article can be found at http://rsta.royalsocietypublishing.org/content/368/1921/2961
dc.subject.other Diagnòstic per la imatge
dc.subject.other Aneurismes cerebrals
dc.title Toward integrated management of cerebral aneurysms
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1098/rsta.2010.0095
dc.subject.keyword Cerebral aneurysms
dc.subject.keyword Image segmentation
dc.subject.keyword Morphological characterization
dc.subject.keyword Computational haemodynamics
dc.subject.keyword Virtual treatment
dc.subject.keyword Virtual physiological human
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/027703
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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