Stable complexes involving acetylcholinesterase and amyloid-ß-peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils

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Alvarez A, Alarcón R, Opazo C, Campos EO, Muñoz FJ, Calderón FH, Dajas F, Gentry MK, Doctor BP, De Mello FG, Inestrosa NC. Stable complexes involving acetylcholinesterase and amyloid-ß-peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils. J Neurosci. 1998; 18(9): 3213-23
http://hdl.handle.net/10230/16675
To cite or link this document: http://hdl.handle.net/10230/16675
dc.contributor.author Álvarez, Alejandra
dc.contributor.author Alarcón, Rodrigo
dc.contributor.author Opazo, Carlos
dc.contributor.author Campos, Eliseo O.
dc.contributor.author Muñoz López, Francisco José, 1964-
dc.contributor.author Calderón, Frances H.
dc.contributor.author Dajas, Federico
dc.contributor.author Gentry, Mary K.
dc.contributor.author Doctor, Bhupendra P.
dc.contributor.author Mello, Fernando G. de
dc.contributor.author Inestrosa, Nibaldo C.
dc.date.accessioned 2012-07-05T06:54:28Z
dc.date.available 2012-07-05T06:54:28Z
dc.date.issued 1998
dc.identifier.citation Alvarez A, Alarcón R, Opazo C, Campos EO, Muñoz FJ, Calderón FH, Dajas F, Gentry MK, Doctor BP, De Mello FG, Inestrosa NC. Stable complexes involving acetylcholinesterase and amyloid-ß-peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils. J Neurosci. 1998; 18(9): 3213-23
dc.identifier.issn 0270-6474
dc.identifier.uri http://hdl.handle.net/10230/16675
dc.description.abstract Brain acetylcholinesterase (AChE) forms stable complexes with amyloid-beta peptide (Abeta) during its assembly into filaments, in agreement with its colocalization with the Abeta deposits of Alzheimer's brain. The association of the enzyme with nascent Abeta aggregates occurs as early as after 30 min of incubation. Analysis of the catalytic activity of the AChE incorporated into these complexes shows an anomalous behavior reminiscent of the AChE associated with senile plaques, which includes a resistance to low pH, high substrate concentrations, and lower sensitivity to AChE inhibitors. Furthermore, the toxicity of the AChE-amyloid complexes is higher than that of the Abeta aggregates alone. Thus, in addition to its possible role as a heterogeneous nucleator during amyloid formation, AChE, by forming such stable complexes, may increase the neurotoxicity of Abeta fibrils and thus may determine the selective neuronal loss observed in Alzheimer's brain.
dc.language.iso eng
dc.publisher Society for Neuroscience
dc.relation.ispartof J Neurosci. 1998; 18(9): 3213-23
dc.rights (c) 1998, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/18/9/3213
dc.subject.other Alzheimer, Malaltia d' -- Fisiologia patològica
dc.subject.other Proteïna beta-amiloide
dc.title Stable complexes involving acetylcholinesterase and amyloid-ß-peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils
dc.type info:eu-repo/semantics/article
dc.subject.keyword AChE
dc.subject.keyword Ab-amyloid fibrils
dc.subject.keyword AChE-Ab-amyloid fibril complexes
dc.subject.keyword Amyloid formation
dc.subject.keyword Alzheimer’s disease
dc.subject.keyword Neurotoxicity
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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