Impairment of mossy fiber long-term potentiation and associative learning in pituitary adenylate cyclase activating polypeptide type I receptor-deficient Mice

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Otto C, Kovalchuk Y, Wolfer DP, Gass P, Martin M, Zuschratter W, Gröne HJ, Kellendonk C, Tronche F, Maldonado R, Lipp HP, Konnerth A, Schütz G.. Impairment of mossy fiber long-term potentiation and associative learning in pituitary adenylate cyclase activating polypeptide type I receptor-deficient Mice. J Neurosci. 2001; 21(15): 5520-7
http://hdl.handle.net/10230/16668
To cite or link this document: http://hdl.handle.net/10230/16668
dc.contributor.author Otto, Christiane
dc.contributor.author Kovalchuk, Yury
dc.contributor.author Wolfer, David Paul
dc.contributor.author Gass, Peter
dc.contributor.author Martin, Miguel
dc.contributor.author Zuschratter, Werner
dc.contributor.author Gröne, Hermann Josef
dc.contributor.author Kellendonk, Christoph
dc.contributor.author Tronche, François
dc.contributor.author Maldonado, Rafael, 1961-
dc.contributor.author Lipp, Hans-Peter
dc.contributor.author Konnerth, Arthur
dc.contributor.author Schütz, Günter
dc.date.accessioned 2012-07-05T06:54:15Z
dc.date.available 2012-07-05T06:54:15Z
dc.date.issued 2001
dc.identifier.citation Otto C, Kovalchuk Y, Wolfer DP, Gass P, Martin M, Zuschratter W, Gröne HJ, Kellendonk C, Tronche F, Maldonado R, Lipp HP, Konnerth A, Schütz G.. Impairment of mossy fiber long-term potentiation and associative learning in pituitary adenylate cyclase activating polypeptide type I receptor-deficient Mice. J Neurosci. 2001; 21(15): 5520-7
dc.identifier.issn 0270-6474
dc.identifier.uri http://hdl.handle.net/10230/16668
dc.description.abstract The pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor (PAC1) is a G-protein-coupled receptor binding the strongly conserved neuropeptide PACAP with 1000-fold higher affinity than the related peptide vasoactive intestinal peptide. PAC1-mediated signaling has been implicated in neuronal differentiation and synaptic plasticity. To gain further insight into the biological significance of PAC1-mediated signaling in vivo, we generated two different mutant mouse strains, harboring either a complete or a forebrain-specific inactivation of PAC1. Mutants from both strains show a deficit in contextual fear conditioning, a hippocampus-dependent associative learning paradigm. In sharp contrast, amygdala-dependent cued fear conditioning remains intact. Interestingly, no deficits in other hippocampus-dependent tasks modeling declarative learning such as the Morris water maze or the social transmission of food preference are observed. At the cellular level, the deficit in hippocampus-dependent associative learning is accompanied by an impairment of mossy fiber long-term potentiation (LTP). Because the hippocampal expression of PAC1 is restricted to mossy fiber terminals, we conclude that presynaptic PAC1-mediated signaling at the mossy fiber synapse is involved in both LTP and hippocampus-dependent associative learning.
dc.language.iso eng
dc.publisher Society for Neuroscience
dc.relation.ispartof J Neurosci. 2001; 21(15): 5520-7
dc.rights (c) 2001, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/21/15/5520
dc.subject.other Xarxes neuronals (Neurobiologia)
dc.subject.other Neuropèptids
dc.title Impairment of mossy fiber long-term potentiation and associative learning in pituitary adenylate cyclase activating polypeptide type I receptor-deficient Mice
dc.type info:eu-repo/semantics/article
dc.subject.keyword PACAP type I receptor
dc.subject.keyword Knock-out mice
dc.subject.keyword Fear conditioning
dc.subject.keyword Synaptic plasticity
dc.subject.keyword LTP
dc.subject.keyword Mossy fiber
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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