Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice

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Zimmer A, Valjent E, Konig M, Zimmer AM, Robledo P, Hahn H, Valverde O, Maldonado R. Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice. J Neurosci. 2001; 21(23): 9499-505
http://hdl.handle.net/10230/16667
To cite or link this document: http://hdl.handle.net/10230/16667
dc.contributor.author Zimmer, Andreas
dc.contributor.author Valjent, Emmanuel
dc.contributor.author König, Monika
dc.contributor.author Zimmer, Anne M.
dc.contributor.author Robledo, M. Patricia
dc.contributor.author Hahn, Heidi
dc.contributor.author Valverde, Olga
dc.contributor.author Maldonado, Rafael, 1961-
dc.date.accessioned 2012-07-05T06:54:13Z
dc.date.available 2012-07-05T06:54:13Z
dc.date.issued 2001
dc.identifier.citation Zimmer A, Valjent E, Konig M, Zimmer AM, Robledo P, Hahn H, Valverde O, Maldonado R. Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice. J Neurosci. 2001; 21(23): 9499-505
dc.identifier.issn 0270-6474
dc.identifier.uri http://hdl.handle.net/10230/16667
dc.description.abstract The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC analgesia and the absence of THC-induced conditioned place aversion. In contrast, acute and chronic opioid effects were normal. The lack of negative motivational effects of THC in the absence of dynorphin demonstrates that this endogenous opioid peptide mediates the dysphoric effects of marijuana.
dc.language.iso eng
dc.publisher Society for Neuroscience
dc.relation.ispartof J Neurosci. 2001; 21(23): 9499-505
dc.rights (c) 2001, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/21/23/9499
dc.subject.other Cannabinoides -- Efectes fisiològics
dc.subject.other Cannabinoides -- Receptors
dc.title Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice
dc.type info:eu-repo/semantics/article
dc.subject.keyword Cannabinoid
dc.subject.keyword Opioid
dc.subject.keyword Mice
dc.subject.keyword Mutation
dc.subject.keyword Withdrawal
dc.subject.keyword Addiction
dc.subject.keyword Place aversion
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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