Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice

Benvinguts al Repositori Digital de la UPF

Zimmer A, Valjent E, Konig M, Zimmer AM, Robledo P, Hahn H, Valverde O, Maldonado R. Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice. J Neurosci. 2001; 21(23): 9499-505
http://hdl.handle.net/10230/16667
Per citar o enllaçar aquest document: http://hdl.handle.net/10230/16667
dc.contributor.author Zimmer, Andreas
dc.contributor.author Valjent, Emmanuel
dc.contributor.author König, Monika
dc.contributor.author Zimmer, Anne M.
dc.contributor.author Robledo, Patrícia, 1958-
dc.contributor.author Hahn, Heidi
dc.contributor.author Valverde Granados, Olga
dc.contributor.author Maldonado, Rafael, 1961-
dc.date.accessioned 2012-07-05T06:54:13Z
dc.date.available 2012-07-05T06:54:13Z
dc.date.issued 2001
dc.identifier.citation Zimmer A, Valjent E, Konig M, Zimmer AM, Robledo P, Hahn H, Valverde O, Maldonado R. Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice. J Neurosci. 2001; 21(23): 9499-505
dc.identifier.issn 0270-6474
dc.identifier.uri http://hdl.handle.net/10230/16667
dc.description.abstract The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC analgesia and the absence of THC-induced conditioned place aversion. In contrast, acute and chronic opioid effects were normal. The lack of negative motivational effects of THC in the absence of dynorphin demonstrates that this endogenous opioid peptide mediates the dysphoric effects of marijuana.
dc.description.sponsorship This work was supported by European Commission BIOM ED-2 Grant 98-2227 (R.M.), Fondo de Investigaciones Sanitaria Grant 99/0624 (R.M.), Dr. Esteve S. A. Laboratories (R.M.), Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 400), and the Land Nordrhein-Westfalen (Innovationsprogramm Forschung) (A.Z.)
dc.language.iso eng
dc.publisher Society for Neuroscience
dc.relation.ispartof J Neurosci. 2001; 21(23): 9499-505
dc.rights (c) 2001, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/21/23/9499
dc.subject.other Cannabinoides -- Efectes fisiològics
dc.subject.other Cannabinoides -- Receptors
dc.title Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice
dc.type info:eu-repo/semantics/article
dc.subject.keyword Cannabinoid
dc.subject.keyword Opioid
dc.subject.keyword Mice
dc.subject.keyword Mutation
dc.subject.keyword Withdrawal
dc.subject.keyword Addiction
dc.subject.keyword Place aversion
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


Consulteu el text complet

Cerca


Cerca avançada

Visualitza

El meu compte

Estadístiques