Hedgehog signaling governs the development of otic sensory epithelium and its associated innervation in zebrafish

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Sapède D, Pujades C. Hedgehog signaling governs the development of otic sensory epithelium and its associated innervation in zebrafish. J. Neurosci. 2010; 30(10): 3612-23. DOI: 10.1523/JNEUROSCI.5109-09.2010
http://hdl.handle.net/10230/16654
To cite or link this document: http://hdl.handle.net/10230/16654
dc.contributor.author Sapède, Dora
dc.contributor.author Pujades Corbi, Cristina
dc.date.accessioned 2012-07-05T06:53:33Z
dc.date.available 2012-07-05T06:53:33Z
dc.date.issued 2010
dc.identifier.citation Sapède D, Pujades C. Hedgehog signaling governs the development of otic sensory epithelium and its associated innervation in zebrafish. J. Neurosci. 2010; 30(10): 3612-23. DOI: 10.1523/JNEUROSCI.5109-09.2010
dc.identifier.issn 0270-6474
dc.identifier.uri http://hdl.handle.net/10230/16654
dc.description.abstract The inner ear is responsible for the perception of motion and sound in vertebrates. Its functional unit, the sensory patch, contains mechanosensory hair cells innervated by sensory neurons from the statoacoustic ganglion (SAG) that project to the corresponding nuclei in the brainstem. How hair cells develop at specific positions, and how otic neurons are sorted to specifically innervate each endorgan and to convey the extracted information to the hindbrain is not completely understood. In this work, we study the generation of macular sensory patches and investigate the role of Hedgehog (Hh) signaling in the production of their neurosensory elements. Using zebrafish transgenic lines to visualize the dynamics of hair cell and neuron production, we show that the development of the anterior and posterior maculae is asynchronic, suggesting they are independently regulated. Tracing experiments demonstrate the SAG is topologically organized in two different neuronal subpopulations, which are spatially segregated and innervate specifically each macula. Functional experiments identify the Hh pathway as crucial in coordinating the production of hair cells in the posterior macula, and the formation of its specific innervation. Finally, gene expression analyses suggest that Hh influences the balance between different SAG neuronal subpopulations. These results lead to a model in which Hh orients functionally the development of inner ear towards an auditory fate in all vertebrate species.
dc.language.iso eng
dc.publisher Society for Neuroscience
dc.relation.ispartof J. Neurosci. 2010; 30(10): 3612-23
dc.rights (c) 2010, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/30/10/3612
dc.subject.other Laberint (Orella) -- Fisiologia
dc.subject.other Laberint (Orella) -- Fisiologia
dc.subject.other Neurobiologia del desenvolupament
dc.title Hedgehog signaling governs the development of otic sensory epithelium and its associated innervation in zebrafish
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1523/JNEUROSCI.5109-09.2010
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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