Y-chromosome diversity in native mexicans reveals continental transition of genetic structure in the Americas

Welcome to the UPF Digital Repository

Sandoval K, Moreno A, Mendizábal I, Underhill P, López-Valenzuela M, Peñaloza-Espinosa R, Buentello-Malo L, Avelino H, Calafell F, Comas D. Y-chromosome diversity in native mexicans reveals continental transition of genetic structure in the Americas. Am. J. Phys. Anthropol. 2012; 148: 395-405. DOI: 10.1002/ajpa.22062
http://hdl.handle.net/10230/16649
To cite or link this document: http://hdl.handle.net/10230/16649
dc.contributor.author Sandoval Mendoza, Karla
dc.contributor.author Moreno Estrada, Andrés
dc.contributor.author Mendizábal Eceizabarrena, Isabel, 1981-
dc.contributor.author Underhill, Peter
dc.contributor.author López Valenzuela, María
dc.contributor.author Peñaloza Espinosa, Rosenda
dc.contributor.author Buentello Malo, Leonor
dc.contributor.author Avelino, Heriberto
dc.contributor.author Calafell i Majó, Francesc
dc.contributor.author Comas, David
dc.date.accessioned 2012-07-05T06:47:46Z
dc.date.available 2012-07-05T06:47:46Z
dc.date.issued 2012
dc.identifier.citation Sandoval K, Moreno A, Mendizábal I, Underhill P, López-Valenzuela M, Peñaloza-Espinosa R, Buentello-Malo L, Avelino H, Calafell F, Comas D. Y-chromosome diversity in native mexicans reveals continental transition of genetic structure in the Americas. Am. J. Phys. Anthropol. 2012; 148: 395-405. DOI: 10.1002/ajpa.22062
dc.identifier.issn 1096-8644
dc.identifier.uri http://hdl.handle.net/10230/16649
dc.description.abstract The genetic characterization of Native Mexicans is important to understand multiethnic based features influencing the medical genetics of present Mexican populations, as well as to the reconstruct the peopling of the Americas. We describe the Y-chromosome genetic diversity of 197 Native Mexicans from 11 populations and 1,044 individuals from 44 Native American populations after combining with publicly available data. We found extensive heterogeneity among Native Mexican populations and ample segregation of Q-M242* (46%) and Q-M3 (54%) haplogroups within Mexico. The northernmost sampled populations falling outside Mesoamerica (Pima and Tarahumara) showed a clear differentiation with respect to the other populations, which is in agreement with previous results from mtDNA lineages. However, our results point toward a complex genetic makeup of Native Mexicans whose maternal and paternal lineages reveal different narratives of their population history, with sex-biased continental contributions and different admixture proportions. At a continental scale, we found that Arctic populations and the northernmost groups from North America cluster together, but we did not find a clear differentiation within Mesoamerica and the rest of the continent, which coupled with the fact that the majority of individuals from Central and South American samples are restricted to the Q-M3 branch, supports the notion that most Native Americans from Mesoamerica southwards are descendants from a single wave of migration. This observation is compatible with the idea that present day Mexico might have constituted an area of transition in the diversification of paternal lineages during the colonization of the Americas.
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Am. J. Phys. Anthropol. 2012; 148: 395-405
dc.rights (c) 2012 WILEY-LISS, INC. This is the pre-peer reviewed version of the following article: Sandoval K, Moreno A, Mendizábal I, Underhill P, López-Valenzuela M, Peñaloza-Espinosa R, Buentello-Malo L, Avelino H, Calafell F, Comas D. Y-chromosome diversity in native mexicans reveals continental transition of genetic structure in the Americas. American journal of physical anthropoky. 2012, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/ajpa.22062/abstract
dc.subject.other Genètica de poblacions humanes -- Mèxic
dc.subject.other Indis de Mèxic -- Aspectes genètics
dc.subject.other Indis de l'Amèrica Central -- Aspectes genètics
dc.title Y-chromosome diversity in native mexicans reveals continental transition of genetic structure in the Americas
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1002/ajpa.22062
dc.subject.keyword Y-chromosome haplogroups
dc.subject.keyword Native Mexican populations
dc.subject.keyword Mesoamerica
dc.subject.keyword Genetic diversity
dc.subject.keyword Male lineages
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


See full text

Search


Advanced Search

Browse

My Account

Statistics