Blood levels of brain-derived neurotrophic factor correlate with several psychopathological symptoms in anorexia nervosa patients

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Mercader JM, Fernández-Aranda F, Gratacòs M, Ribasés M, Badía A, Villarejo C, Solano R, González JR, Vallejo J, Estivill X. Blood levels of brain-derived neurotrophic factor correlate with several psychopathological symptoms in anorexia nervosa patients. Neuropsychobiology. 2007; 56(4): 185-90. DOI: 10.1159/000120623
http://hdl.handle.net/10230/16494
To cite or link this document: http://hdl.handle.net/10230/16494
dc.contributor.author Mercader Bigas, Josep Maria
dc.contributor.author Fernández Aranda, Fernando
dc.contributor.author Gratacós Mayora, Mònica
dc.contributor.author Ribasés, Marta
dc.contributor.author Badía, Anna
dc.contributor.author Villarejo, Cynthia
dc.contributor.author Solano, Raquel
dc.contributor.author González, Juan Ramón
dc.contributor.author Vallejo, Julio
dc.contributor.author Estivill, Xavier
dc.date.accessioned 2012-05-31T10:32:55Z
dc.date.available 2012-05-31T10:32:55Z
dc.date.issued 2007
dc.identifier.citation Mercader JM, Fernández-Aranda F, Gratacòs M, Ribasés M, Badía A, Villarejo C, Solano R, González JR, Vallejo J, Estivill X. Blood levels of brain-derived neurotrophic factor correlate with several psychopathological symptoms in anorexia nervosa patients. Neuropsychobiology. 2007; 56(4): 185-90. DOI: 10.1159/000120623
dc.identifier.issn 0302-282X
dc.identifier.uri http://hdl.handle.net/10230/16494
dc.description.abstract Background: Evidence of a role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of eating disorders (ED) has been provided by association studies and by murine models. BDNF plasma levels have been found altered in ED and in psychiatric disorders that show comorbidity with ED. Aims: Since the role of BDNF levels in ED-related psychopathological symptoms has not been tested, we investigated the correlation of BDNF plasma levels with the Symptom Checklist 90 Revised (SCL-90R) questionnaire in a total of 78 ED patients. Methods: BDNF levels, measured by the enzyme-linked immunoassay system, and SCL-90R questionnaire, were assessed in a total of 78 ED patients. The relationship between BDNF levels and SCL-90R scales was calculated using a general linear model. Results: BDNF plasma levels correlated with the Global Severity Index and the Positive Symptom Distress Index global scales and five of the nine subscales in the anorexia nervosa patients. BDNF plasma levels were able to explain, in the case of the Psychoticism subscale, up to 17% of the variability (p = 0.006). Conclusion: Our data suggest that BDNF levels could be involved in the severity of the disease through the modulation of psychopathological traits that are associated with the ED phenotype.
dc.language.iso eng
dc.publisher Karger (S. Karger AG)
dc.relation.ispartof Neuropsychobiology. 2007; 56(4): 185-90
dc.rights (c) 2007 S. Karger AG, Basel
dc.subject.other Trastorns de la conducta alimentària -- Aspectes genètics
dc.subject.other Anorèxia nerviosa
dc.subject.other Bulímia
dc.title Blood levels of brain-derived neurotrophic factor correlate with several psychopathological symptoms in anorexia nervosa patients
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1159/000120623
dc.subject.keyword Brain-derived neurotrophic factor
dc.subject.keyword Eating disorders
dc.subject.keyword Anorexia nervosa
dc.subject.keyword Bulimia nervosa
dc.subject.keyword Psychopathology
dc.subject.keyword Anxiety
dc.subject.keyword Depression
dc.subject.keyword Obsessive-compulsiveness
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/submittedVersion


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