Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx/anx mouse model

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Mercader JM, Lozano JJ, Sumoy L, Dierssen M, Visa J, Gratacòs M, Estivill X. Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx/anx mouse model. Physiol. Genomics. 2008; 35(3): 341-50. DOI: 10.1152/physiolgenomics.90255.2008
http://hdl.handle.net/10230/16492
To cite or link this document: http://hdl.handle.net/10230/16492
dc.contributor.author Mercader Bigas, Josep Maria
dc.contributor.author Lozano, Juan José
dc.contributor.author Sumoy Van Dyck, Lauro
dc.contributor.author Dierssen, Mara
dc.contributor.author Visa, Joana
dc.contributor.author Gratacós Mayora, Mònica
dc.contributor.author Estivill, Xavier, 1955-
dc.date.accessioned 2012-05-31T10:32:50Z
dc.date.available 2012-05-31T10:32:50Z
dc.date.issued 2008
dc.identifier.citation Mercader JM, Lozano JJ, Sumoy L, Dierssen M, Visa J, Gratacòs M, Estivill X. Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx/anx mouse model. Physiol. Genomics. 2008; 35(3): 341-50. DOI: 10.1152/physiolgenomics.90255.2008
dc.identifier.issn 1094-8341
dc.identifier.uri http://hdl.handle.net/10230/16492
dc.description.abstract The anx/anx mouse displays poor appetite and lean appearance and is considered a good model for the study of anorexia nervosa. To identify new genes involved in feeding behavior and body weight regulation we performed an expression profiling in the hypothalamus of the anx/anx mice. Using commercial microarrays we detected 156 differentially expressed genes and validated 92 of those using TaqMan low-density arrays. The expression of a set of 87 candidate genes selected based on literature evidences was also quantified by TaqMan low-density arrays. Our results showed enrichment in deregulated genes involved in cell death, cell morphology and cancer as well as an alteration of several signaling circuits involved in energy balance including neuropeptide Y and melanocortin signaling. The expression profile along with the phenotype led us to conclude that anx/anx mice resemble the anorexia-cachexia syndrome typically observed in cancer, infection with human immunodeficiency virus or chronic diseases, rather than starvation, and that anx/anx mice could be considered a good model for the treatment and investigation of this condition.
dc.language.iso eng
dc.publisher American Physiological Society
dc.relation.ispartof Physiol. Genomics. 2008; 35(3): 341-50
dc.rights (c) 2008, American Physiological Society
dc.subject.other Anorèxia nerviosa
dc.subject.other Trastorns de la conducta alimentària -- Aspectes genètics
dc.subject.other Trastorns de la conducta alimentària -- Models animals
dc.title Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx/anx mouse model
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1152/physiolgenomics.90255.2008
dc.subject.keyword Cachexia
dc.subject.keyword Anx/anx
dc.subject.keyword Anorexia
dc.subject.keyword Hypothalamus
dc.subject.keyword Transcriptome
dc.subject.keyword Feeding regulation
dc.subject.keyword Chronic disorders
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/submittedVersion


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