Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21

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Lyle R, Prandini P, Osoegawa K, ten Hallers B, Humphray S, Zhu B, Eyras E, Castelo R, Bird CP, Gagos S, Scott C, Cox A, Deutsch S, Ucla C, Cruts M, Dahoun S, She X, Bena F, Wang SY, Van Broeckhoven C, Eichler EE, Guigo R, Rogers J, de Jong PJ, Reymond A, Antonarakis SE. Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21. Genome Res. 2007; 17(11): 1690-6. DOI: 10.1101/gr.6675307
http://hdl.handle.net/10230/16476
To cite or link this document: http://hdl.handle.net/10230/16476
dc.contributor.author Lyle, Robert
dc.contributor.author Prandini, Paola
dc.contributor.author Osoegawa, Kazutoyo
dc.contributor.author Ten Hallers, Boudewijn
dc.contributor.author Humphray, Sean
dc.contributor.author Zhu, Baoli
dc.contributor.author Eyras Jiménez, Eduardo
dc.contributor.author Castelo, Robert
dc.contributor.author Bird, Christine P.
dc.contributor.author Gagos, Sarantos
dc.contributor.author Scott, Carol
dc.contributor.author Cox, Antony
dc.contributor.author Deutsch, Samuel
dc.contributor.author Ucla, Catherine
dc.contributor.author Cruts, Marc
dc.contributor.author Dahoun, Sophie
dc.contributor.author She, Xinwei
dc.contributor.author Bena, Frederique
dc.contributor.author Wang, Sheng-Yue
dc.contributor.author Van Broeckhoven, Christine
dc.contributor.author Eichler, Evan E.
dc.contributor.author Guigó Serra, Roderic
dc.contributor.author Rogers, Jane
dc.contributor.author De Jong, Pieter J.
dc.contributor.author Reymond, Alexandre
dc.contributor.author Antonarakis, Stylianos E.
dc.date.accessioned 2012-05-21T09:45:06Z
dc.date.available 2012-05-21T09:45:06Z
dc.date.issued 2007
dc.identifier.citation Lyle R, Prandini P, Osoegawa K, ten Hallers B, Humphray S, Zhu B, Eyras E, Castelo R, Bird CP, Gagos S, Scott C, Cox A, Deutsch S, Ucla C, Cruts M, Dahoun S, She X, Bena F, Wang SY, Van Broeckhoven C, Eichler EE, Guigo R, Rogers J, de Jong PJ, Reymond A, Antonarakis SE. Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21. Genome Res. 2007; 17(11): 1690-6. DOI: 10.1101/gr.6675307
dc.identifier.issn 1088-9051
dc.identifier.uri http://hdl.handle.net/10230/16476
dc.description.abstract The goals of the human genome project did not include sequencing of the heterochromatic regions. We describe here an initial sequence of 1.1 Mb of the short arm of human chromosome 21 (HSA21p), estimated to be 10% of 21p. This region contains extensive euchromatic-like sequence and includes on average one transcript every 100 kb. These transcripts show multiple inter- and intrachromosomal copies, and extensive copy number and sequence variability. The sequencing of the "heterochromatic" regions of the human genome is likely to reveal many additional functional elements and provide important evolutionary information.
dc.language.iso eng
dc.publisher Cold Spring Harbor Laboratory Press-CSHL Press
dc.rights © 2007 Genome Research by Cold Spring Harbor Laboratory Press. Published version available at http://genome.cshlp.org. Aquest document està subjecte a Llicència Creative Commons (Attribution-NonCommercial 3.0 Unported License)
dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
dc.subject.other Cromosomes humans
dc.subject.other Genoma humà
dc.subject.other Factors de transcripció
dc.title Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21
dc.type info:eu-repo/semantics/article
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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