Comparison of splice sites in mammals and chicken

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Abril JF, Castelo R, Guigó R. Comparison of splice sites in mammals and chicken. Genome Res. 2005; 15(1): 111-9. DOI: 10.1101/gr.3108805
http://hdl.handle.net/10230/16467
To cite or link this document: http://hdl.handle.net/10230/16467
dc.contributor.author Abril Ferrando, Josep Francesc
dc.contributor.author Castelo, Robert
dc.contributor.author Guigó Serra, Roderic
dc.date.accessioned 2012-05-21T09:44:48Z
dc.date.available 2012-05-21T09:44:48Z
dc.date.issued 2005
dc.identifier.citation Abril JF, Castelo R, Guigó R. Comparison of splice sites in mammals and chicken. Genome Res. 2005; 15(1): 111-9. DOI: 10.1101/gr.3108805
dc.identifier.issn 1088-9051
dc.identifier.uri http://hdl.handle.net/10230/16467
dc.description.abstract We have carried out an initial analysis of the dynamics of the recent evolution of the splice-sites sequences on a large collection of human, rodent (mouse and rat), and chicken introns. Our results indicate that the sequences of splice sites are largely homogeneous within tetrapoda. We have also found that orthologous splice signals between human and rodents and within rodents are more conserved than unrelated splice sites, but the additional conservation can be explained mostly by background intron conservation. In contrast, additional conservation over background is detectable in orthologous mammalian and chicken splice sites. Our results also indicate that the U2 and U12 intron classes seem to have evolved independently since the split of mammals and birds; we have not been able to find a convincing case of interconversion between these two classes in our collections of orthologous introns. Similarly, we have not found a single case of switching between AT-AC and GT-AG subtypes within U12 introns, suggesting that this event has been a rare occurrence in recent evolutionary times. Switching between GT-AG and the noncanonical GC-AG U2 subtypes, on the contrary, does not appear to be unusual; in particular, T to C mutations appear to be relatively well tolerated in GT-AG introns with very strong donor sites.
dc.language.iso eng
dc.publisher Cold Spring Harbor Laboratory Press-CSHL Press
dc.relation.ispartof Genome Res. 2005; 15(1): 111-9
dc.rights © 2005 Genome Research by Cold Spring Harbor Laboratory Press. Published version available at http://genome.cshlp.org. Aquest document està subjecte a Llicència Creative Commons (Attribution-NonCommercial 3.0 Unported License)
dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
dc.subject.other ARN empalmament
dc.subject.other Regulació genètica
dc.title Comparison of splice sites in mammals and chicken
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1101/gr.3108805
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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