A bi-dimensional genome scan for prolificacy traits in pigs shows the existence of multiple epistatic QTL

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Noguera JL, Rodríguez C, Varona L, Tomàs A, Muñoz G, Ramírez O, Barragán C, Arqué M, Bidanel JP, Amills M, Ovilo C, Sánchez A. A bi-dimensional genome scan for prolificacy traits in pigs shows the existence of multiple epistatic QTL. BMC Genomics. 2009; 10: 636. DOI: 10.1186/1471-2164-10-636
http://hdl.handle.net/10230/16459
To cite or link this document: http://hdl.handle.net/10230/16459
dc.contributor.author Noguera, José L.
dc.contributor.author Rodríguez, Carmen
dc.contributor.author Varona, Luis
dc.contributor.author Tomàs, Anna
dc.contributor.author Muñoz, Gloria
dc.contributor.author Ramírez, Óscar
dc.contributor.author Barragán, Carmen
dc.contributor.author Arqué, Meritxell
dc.contributor.author Bidanel, Jean P.
dc.contributor.author Amills, Marcel
dc.contributor.author Ovilo, Cristina
dc.contributor.author Sánchez, Armand
dc.date.accessioned 2012-05-11T07:29:25Z
dc.date.available 2012-05-11T07:29:25Z
dc.date.issued 2009
dc.identifier.citation Noguera JL, Rodríguez C, Varona L, Tomàs A, Muñoz G, Ramírez O, Barragán C, Arqué M, Bidanel JP, Amills M, Ovilo C, Sánchez A. A bi-dimensional genome scan for prolificacy traits in pigs shows the existence of multiple epistatic QTL. BMC Genomics. 2009; 10: 636. DOI: 10.1186/1471-2164-10-636
dc.identifier.issn 1471-2164
dc.identifier.uri http://hdl.handle.net/10230/16459
dc.description.abstract Background: Prolificacy is the most important trait influencing the reproductive efficiency of pig production systems. The low heritability and sex-limited expression of prolificacy have hindered to some extent the improvement of this trait through artificial selection. Moreover, the relative contributions of additive, dominant and epistatic QTL to the genetic variance of pig prolificacy remain to be defined. In this work, we have undertaken this issue by performing one-dimensional and bi-dimensional genome scans for number of piglets born alive (NBA) and total number of piglets born (TNB) in a three generation Iberian by Meishan F2 intercross. Results: The one-dimensional genome scan for NBA and TNB revealed the existence of two genome-wide highly significant QTL located on SSC13 (P < 0.001) and SSC17 (P < 0.01) with effects on both traits. This relative paucity of significant results contrasted very strongly with the wide array of highly significant epistatic QTL that emerged in the bi-dimensional genome-wide scan analysis. As much as 18 epistatic QTL were found for NBA (four at P < 0.01 and five at P < 0.05) and TNB (three at P < 0.01 and six at P < 0.05), respectively. These epistatic QTL were distributed in multiple genomic regions, which covered 13 of the 18 pig autosomes, and they had small individual effects that ranged between 3 to 4% of the phenotypic variance. Different patterns of interactions (a × a, a × d, d × a and d × d) were found amongst the epistatic QTL pairs identified in the current work. Conclusions: The complex inheritance of prolificacy traits in pigs has been evidenced by identifying multiple additive (SSC13 and SSC17), dominant and epistatic QTL in an Iberian × Meishan F2 intercross. Our results demonstrate that a significant fraction of the phenotypic variance of swine prolificacy traits can be attributed to first-order gene-by-gene interactions emphasizing that the phenotypic effects of alleles might be strongly modulated by the genetic background where they segregate.
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof BMC Genomics. 2009; 10: 636
dc.rights (c) 2009 Noguera et al. Creative Commons Attribution License
dc.rights.uri http://creativecommons.org/licenses/by/2.0/
dc.subject.other Genòmica
dc.subject.other Interaccions ARN-proteïnes
dc.title A bi-dimensional genome scan for prolificacy traits in pigs shows the existence of multiple epistatic QTL
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/1471-2164-10-636
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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