Generation of cardiomyocytes from new human embrionic stem cell lines derived from poor-quanlity blastocysts

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Raya A, Rodríguez-Pizà I, Arán B, Consiglio A, Barri PN, Veiga A, Izpisúa Belmonte JC. Generation of cardiomyocytes from new human embryonic stem cell lines derived from poor-quality blastocysts. Cold Spring Harb Symp Quant Biol. 2008; 73: 127-35. DOI: 10.1101/sqb.2008.73.038
http://hdl.handle.net/10230/16403
To cite or link this document: http://hdl.handle.net/10230/16403
dc.contributor.author Raya Chamorro, Ángel
dc.contributor.author Rodríguez Pizà, Ignasi
dc.contributor.author Aran, Begoña
dc.contributor.author Consiglio, Antonella
dc.contributor.author Barri, Pere N.
dc.contributor.author Veiga, Anna
dc.contributor.author Izpisúa Belmonte, J. C.
dc.date.accessioned 2012-05-07T11:48:32Z
dc.date.available 2012-05-07T11:48:32Z
dc.date.issued 2008
dc.identifier.citation Raya A, Rodríguez-Pizà I, Arán B, Consiglio A, Barri PN, Veiga A, Izpisúa Belmonte JC. Generation of cardiomyocytes from new human embryonic stem cell lines derived from poor-quality blastocysts. Cold Spring Harb Symp Quant Biol. 2008; 73: 127-35. DOI: 10.1101/sqb.2008.73.038
dc.identifier.issn 0091-7451
dc.identifier.uri http://hdl.handle.net/10230/16403
dc.description.abstract Human embryonic stem (hES) cells represent a potential source for cell replacement therapy of many degenerative diseases. Most frequently, hES cell lines are derived from surplus embryos from assisted reproduction cycles, independent of their quality or morphology. Here, we show that hES cell lines can be obtained from poor-quality blastocysts with the same efficiency as that obtained from good- or intermediate-quality blastocysts. Furthermore, we show that the self-renewal, pluripotency, and differentiation ability of hES cell lines derived from either source are comparable. Finally, we present a simple and reproducible embryoid body-based protocol for the differentiation of hES cells into functional cardiomyocytes. The five new hES cell lines derived here should widen the spectrum of available resources for investigating the biology of hES cells and advancing toward efficient strategies of regenerative medicine.
dc.language.iso eng
dc.publisher Cold Spring Harbor Laboratory Press-CSHL Press
dc.relation.ispartof Cold Spring Harb Symp Quant Biol. 2008; 73: 127-35
dc.rights © 2008, Cold Spring Harbor symposia on quantitative biology by Cold Spring Harbor Laboratory Press. Published version available at http://symposium.cshlp.org/content/73/127.long
dc.subject.other Cél·lules mare embrionàries
dc.subject.other Medicina regenerativa
dc.title Generation of cardiomyocytes from new human embrionic stem cell lines derived from poor-quanlity blastocysts
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1101/sqb.2008.73.038
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/submittedVersion


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