The genomic distribution of intraspecific and interspecific sequence divergence of human segmental duplications relative to human/chimpanzee chromosomal rearrangements

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Marquès-Bonet T, Cheng Z, She X, Eichler EE, Navarro A. The genomic distribution of intraspecific and interspecific sequence divergence of human segmental duplications relative to human/chimpanzee chromosomal rearrangements. BMC Genomics. 2008; 9: 384. DOI 10.1186/1471-2164-9-384
http://hdl.handle.net/10230/16388
To cite or link this document: http://hdl.handle.net/10230/16388
dc.contributor.author Marquès i Bonet, Tomàs, 1975-
dc.contributor.author Cheng, Ze
dc.contributor.author She, Xinwei
dc.contributor.author Eichler, Evan E.
dc.contributor.author Navarro i Cuartiellas, Arcadi, 1969-
dc.date.accessioned 2012-05-03T08:26:00Z
dc.date.available 2012-05-03T08:26:00Z
dc.date.issued 2008
dc.identifier.citation Marquès-Bonet T, Cheng Z, She X, Eichler EE, Navarro A. The genomic distribution of intraspecific and interspecific sequence divergence of human segmental duplications relative to human/chimpanzee chromosomal rearrangements. BMC Genomics. 2008; 9: 384. DOI 10.1186/1471-2164-9-384
dc.identifier.issn 1471-2164
dc.identifier.uri http://hdl.handle.net/10230/16388
dc.description.abstract Background: It has been suggested that chromosomal rearrangements harbor the molecular footprint of the biological phenomena which they induce, in the form, for instance, of changes in the sequence divergence rates of linked genes. So far, all the studies of these potential associations have focused on the relationship between structural changes and the rates of evolution of single-copy DNA and have tried to exclude segmental duplications (SDs). This is paradoxical, since SDs are one of the primary forces driving the evolution of structure and function in our genomes and have been linked not only with novel genes acquiring new functions, but also with overall higher DNA sequence divergence and major chromosomal rearrangements. Results: Here we take the opposite view and focus on SDs. We analyze several of the features of SDs, including the rates of intraspecific divergence between paralogous copies of human SDs and of interspecific divergence between human SDs and chimpanzee DNA. We study how divergence measures relate to chromosomal rearrangements, while considering other factors that affect evolutionary rates in single copy DNA. Conclusion: We find that interspecific SD divergence behaves similarly to divergence of single-copy DNA. In contrast, old and recent paralogous copies of SDs do present different patterns of intraspecific divergence. Also, we show that some relatively recent SDs accumulate in regions that carry inversions in sister lineages.
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof BMC Genomics. 2008; 9: 384
dc.rights (c) 2008 Marquès-Bonet et al. Creative Commons Attribution License
dc.rights.uri http://creativecommons.org/licenses/by/2.0/
dc.subject.other Genoma humà
dc.subject.other Evolució humana
dc.subject.other ADN
dc.title The genomic distribution of intraspecific and interspecific sequence divergence of human segmental duplications relative to human/chimpanzee chromosomal rearrangements
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/1471-2164-9-384
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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