THC prevents MDMA neurotoxicity in mice

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Touriño C, Zimmer A, Valverde O. THC Prevents MDMA Neurotoxicity in Mice. PLoS ONE. 2010; 5(2): e9143. DOI: 10.1371/journal.pone.0009143
http://hdl.handle.net/10230/16378
To cite or link this document: http://hdl.handle.net/10230/16378
dc.contributor.author Touriño Raposo, Clara
dc.contributor.author Zimmer, Andreas
dc.contributor.author Valverde Granados, Olga
dc.date.accessioned 2012-04-20T09:07:11Z
dc.date.available 2012-04-20T09:07:11Z
dc.date.issued 2010
dc.identifier.citation Touriño C, Zimmer A, Valverde O. THC Prevents MDMA Neurotoxicity in Mice. PLoS ONE. 2010; 5(2): e9143. DOI: 10.1371/journal.pone.0009143
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/16378
dc.description.abstract The majority of MDMA (ecstasy) recreational users also consume cannabis. Despite the rewarding effects that both drugs have, they induce several opposite pharmacological responses. MDMA causes hyperthermia, oxidative stress and neuronal damage, especially at warm ambient temperature. However, THC, the main psychoactive compound of cannabis, produces hypothermic, anti-inflammatory and antioxidant effects. Therefore, THC may have a neuroprotective effect against MDMA-induced neurotoxicity. Mice receiving a neurotoxic regimen of MDMA (20 mg/kg ×4) were pretreated with THC (3 mg/kg ×4) at room (21°C) and at warm (26°C) temperature, and body temperature, striatal glial activation and DA terminal loss were assessed. To find out the mechanisms by which THC may prevent MDMA hyperthermia and neurotoxicity, the same procedure was carried out in animals pretreated with the CB1 receptor antagonist AM251 and the CB2 receptor antagonist AM630, as well as in CB1, CB2 and CB1/CB2 deficient mice. THC prevented MDMA-induced-hyperthermia and glial activation in animals housed at both room and warm temperature. Surprisingly, MDMA-induced DA terminal loss was only observed in animals housed at warm but not at room temperature, and this neurotoxic effect was reversed by THC administration. However, THC did not prevent MDMA-induced hyperthermia, glial activation, and DA terminal loss in animals treated with the CB1 receptor antagonist AM251, neither in CB1 and CB1/CB2 knockout mice. On the other hand, THC prevented MDMA-induced hyperthermia and DA terminal loss, but only partially suppressed glial activation in animals treated with the CB2 cannabinoid antagonist and in CB2 knockout animals. Our results indicate that THC protects against MDMA neurotoxicity, and suggest that these neuroprotective actions are primarily mediated by the reduction of hyperthermia through the activation of CB1 receptor, although CB2 receptors may also contribute to attenuate neuroinflammation in this process.
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS ONE. 2010; 5(2): e9143
dc.rights © Touriño et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/2.5/
dc.subject.other MDMA (Droga)
dc.subject.other Drogues
dc.subject.other Cannabinoides -- Efectes fisiològics
dc.title THC prevents MDMA neurotoxicity in mice
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0009143
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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