MDMA attenuates THC withdrawal syndrome in mice

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Touriño C, Maldonado R, Valverde O. MDMA attenuates THC withdrawal syndrome in mice. Psychopharmacology. 2007; 193(1): 75-84. DOI: 10.1007/s00213-007-0772-5
http://hdl.handle.net/10230/16366
To cite or link this document: http://hdl.handle.net/10230/16366
dc.contributor.author Touriño Raposo, Clara
dc.contributor.author Maldonado, Rafael
dc.contributor.author Valverde Granados, Olga
dc.date.accessioned 2012-04-16T16:10:00Z
dc.date.available 2012-04-16T16:10:00Z
dc.date.issued 2007
dc.identifier.citation Touriño C, Maldonado R, Valverde O. MDMA attenuates THC withdrawal syndrome in mice. Psychopharmacology. 2007; 193(1): 75-84. DOI: 10.1007/s00213-007-0772-5
dc.identifier.issn 0033-3158
dc.identifier.uri http://hdl.handle.net/10230/16366
dc.description.abstract 3, 4-Methylenedioxymethamphetamine (MDMA) and cannabis are widely abused illicit drugs that are frequently consumed in combination. Interactions between these two drugs have been reported in several pharmacological responses observed in animals, such as body temperature, anxiety, cognition and reward. However, the interaction between MDMA and cannabis in addictive processes such as physical dependence has not been elucidated yet. In this study, the effects of acute and chronic MDMA were evaluated on the behavioral manifestations of Δ9-tetrahydrocannabinol (THC) abstinence in mice. THC withdrawal syndrome was precipitated by injecting the cannabinoid antagonist rimonabant (10 mg/kg, i.p.) in mice chronically treated with THC, and receiving MDMA (2.5, 5 and 10 mg/kg i.p.) or saline just before the withdrawal induction or chronically after the THC administration. Both, chronic and acute MDMA decreased in a dose-dependent manner the severity of THC withdrawal. In vivo microdialysis experiments showed that acute MDMA (5 mg/kg, i.p.) administration increased extracellular serotonin levels in the prefrontal cortex, but not dopamine levels in the nucleus accumbens. Our results also indicate that the attenuation of THC abstinence symptoms was not due to a direct interaction between rimonabant and MDMA nor to the result of the locomotor stimulating effects of MDMA. The modulation of the cannabinoid withdrawal syndrome by acute or chronic MDMA suggests a possible mechanism to explain the associated consumption of these two drugs in humans.
dc.description.sponsorship This study was supported by grants from Spanish MCYT (SAF 2004/568; BFU 2004/920BFI), Generalitat de Catalunya (2005SGR00131), European Communities (GENADDICT LSHM–CT–2004–005166) and NIH (Extra-mural research project #DA016768). CT has a fellowship supported by the Department of Education and Universities from Generalitat de Catalunya and by the Social European Fund. Ms Dulce Real in this work is kindly acknowledged for her excellent technical assistance in the in vivo microdialysis experiments.
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Psychopharmacology. 2007; 193(1): 75-84
dc.rights (c) 2007 Springer. The original publication is available at www.springerlink.com
dc.subject.other MDMA (Droga)
dc.subject.other Drogues
dc.title MDMA attenuates THC withdrawal syndrome in mice
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1007/s00213-007-0772-5
dc.subject.keyword Psychostimulant
dc.subject.keyword Cannabinoid
dc.subject.keyword Physical dependence
dc.subject.keyword In vivo microdialysis
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/submittedVersion


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