A variant in the gene FUT9 is associated with susceptibility to placental malaria infection

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Sikora M, Ferrer-Admetlla A, Laayouni H, Menendez C, Mayor A, Bardaji A, Sigauque B, Mandomando I, Alonso P L, Bertranpetit J, Casals F. A variant in the gene FUT9 is associated with susceptibility to placental malaria infection. Human Molecular Genetics. 2009; 18(16): 3136-3144. DOI 10.1093/hmg/ddp240
http://hdl.handle.net/10230/16238
To cite or link this document: http://hdl.handle.net/10230/16238
dc.contributor.author Sikora, Martin
dc.contributor.author Ferrer Admetlla, Anna
dc.contributor.author Laayouni, Hafid
dc.contributor.author Menéndez, Clara
dc.contributor.author Mayor, Alfredo
dc.contributor.author Bardaji, Azucena
dc.contributor.author Sigauque, Betuel
dc.contributor.author Mandomando, Inacio
dc.contributor.author Alonso, Pedro L.
dc.contributor.author Bertranpetit, Jaume
dc.contributor.author Casals López, Ferran
dc.contributor.other Universitat Pompeu Fabra
dc.date.accessioned 2012-02-16T11:38:53Z
dc.date.available 2012-02-16T11:38:53Z
dc.date.issued 2009
dc.identifier.citation Sikora M, Ferrer-Admetlla A, Laayouni H, Menendez C, Mayor A, Bardaji A, Sigauque B, Mandomando I, Alonso P L, Bertranpetit J, Casals F. A variant in the gene FUT9 is associated with susceptibility to placental malaria infection. Human Molecular Genetics. 2009; 18(16): 3136-3144. DOI 10.1093/hmg/ddp240
dc.identifier.issn 0340-6717
dc.identifier.uri http://hdl.handle.net/10230/16238
dc.description.abstract Malaria in pregnancy forms a substantial part of the worldwide burden of malaria, with an estimated annual death toll of up to 200,000 infants, as well as increased maternal morbidity and mortality. Studies of genetic susceptibility to malaria have so far focused on infant malaria, with only a few studies investigating the genetic basis of placental malaria, focusing only on a limited number of candidate genes. The aim of this study therefore was to identify novel host genetic factors involved in placental malaria infection. To this end we carried out a nested case-control study on 180 Mozambican pregnant women with placental malaria infection, and 180 controls within an intervention trial of malaria prevention. We genotyped 880 SNPs in a set of 64 functionally related genes involved in glycosylation and innate immunity. A SNP located in the gene FUT9, rs3811070, was significantly associated with placental malaria infection (OR = 2.31, permutation p-value = 0.028). Haplotypic analysis revealed a similarly strong association of a common haplotype of four SNPs including rs3811070. FUT9 codes for a fucosyl-transferase that is catalyzing the last step in the biosynthesis of the Lewis-x antigen, which forms part of the Lewis blood group-related antigens. These results therefore suggest an involvement of this antigen in the pathogenesis of placental malaria infection.
dc.description.sponsorship This work was supported by grant SAF-2007-63171 awarded by Ministerio de Educación y Ciencia (Spain) to JB and the CIBERESP (CIBER of Epidemiology and Public Health, Ministry of Health). Funds were also obtained from Direcció General de Recerca of Generalitat de Catalunya (Grup de Recerca Consolidat 2005SGR/00608) and from Banco de Bilbao, Vizcaya, Argentaria Foundation (grant number BBVA 02-0). The CISM receives core support from the Spanish Agency for International Cooperation and Development (AECID). All the genotyping was provided by the Spanish "Centro Nacional de Genotipado" (CEGEN; www.cegen.org); Support for computations was provided by the National Institute for Bioinformatics (www.inab.org); both are platforms of Genoma España. MS is supported by a PhD fellowship from the Programa de becas FPU del Ministerio de Educación y Ciencia, Spain (AP2005-3982).
dc.language.iso eng
dc.publisher Oxford University Press
dc.rights © Martin Sikora et al. 2009. Published by Oxford University Press. All rights reserved
dc.subject.other Malària -- Aspectes genètics
dc.subject.other Dones embarassades -- Moçambic
dc.title A variant in the gene FUT9 is associated with susceptibility to placental malaria infection
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/hmg/ddp240
dc.subject.keyword Malaria
dc.subject.keyword Mozambique
dc.subject.keyword Pregnancy
dc.subject.keyword Genetics
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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