Mononuclear cell transcriptome response after sustained virgin olive oil consumption in humans: an exploratory nutrigenomics study

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Khymenets O, Fitó M, Covas M I, Farré M, Pujadas M A, Muñoz D, Konstantinidou V, De la Torre R. Mononuclear cell transcriptome response after sustained virgin olive oil consumption in humans: an exploratory nutrigenomics study. OMICS: a journal of integrative biology. 2009; 13(1): 7-19. DOI 10.1089/omi.2008.0079
http://hdl.handle.net/10230/16183
To cite or link this document: http://hdl.handle.net/10230/16183
dc.contributor.author Khymenets, Olha
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Covas Planells, Maria Isabel
dc.contributor.author Farré Albaladejo, Magí
dc.contributor.author Pujadas, María Antonia
dc.contributor.author Muñoz Aguayo, Daniel
dc.contributor.author Konstantinidou, Valentini
dc.contributor.author De la Torre Fornell, Rafael
dc.contributor.other Universitat Pompeu Fabra
dc.date.accessioned 2012-01-31T10:29:45Z
dc.date.available 2012-01-31T10:29:45Z
dc.date.issued 2009
dc.identifier.citation Khymenets O, Fitó M, Covas M I, Farré M, Pujadas M A, Muñoz D, Konstantinidou V, De la Torre R. Mononuclear cell transcriptome response after sustained virgin olive oil consumption in humans: an exploratory nutrigenomics study. OMICS: a journal of integrative biology. 2009; 13(1): 7-19. DOI 10.1089/omi.2008.0079
dc.identifier.issn 1536-2310
dc.identifier.uri http://hdl.handle.net/10230/16183
dc.description.abstract Virgin olive oil (VOO) is considered to be one of the main components responsible for the health benefits of the Mediterranean diet, particularly against atherosclerosis where peripheral blood mononuclear cells (PBMNCs) play a crucial role in atherosclerosis development and progression. The objective of this article was to identify the PBMNC genes that respond to VOO consumption in order to ascertain the molecular mechanisms underlying the beneficial action of VOO in the prevention of atherosclerosis. Gene expression profiles of PBMNCs from healthy individuals were examined in pooled RNA samples by microarrays after 3 weeks of moderate and regular consumption of VOO, as the main fat source in a diet controlled for antioxidant content. Gene expression was verified by qPCR. The response to VOO consumption was confirmed for individual samples (n = 10) by qPCR for 10 upregulated genes (ADAM17, ALDH1A1, BIRC1, ERCC5, LIAS, OGT, PPARBP, TNFSF10, USP48, and XRCC5). Their putative role in the molecular mechanisms involved in atherosclerosis development and progression is discussed, focusing on a possible relation with VOO consumption. Our data support the hypothesis that 3 weeks of nutritional intervention with VOO supplementation, at doses common in the Mediterranean diet, can alter the expression of genes related to atherosclerosis development and progression.
dc.description.sponsorship The CNS Contract CP06/00100 (Montserrat Fitó) is acknowledged. This work has been supported by CICYT (SAF 2004-08173-C03-00) and partially supported by the Generalitat of Catalunya (2005 SGR 0057).
dc.language.iso eng
dc.publisher Mary Ann Liebert, Inc
dc.rights This is a copy of an article published in the OMICS: a journal of integrative biology © 2009 copyright Mary Ann Liebert, Inc.; OMICS: a journal of integrative biology is available online at: http://www.liebertonline.com.
dc.subject.other Oli d'oliva
dc.subject.other Arteriosclerosi -- Prevenció
dc.subject.other Dieta mediterrània
dc.subject.other Nutrició
dc.subject.other Genòmica
dc.subject.other Genètica
dc.title Mononuclear cell transcriptome response after sustained virgin olive oil consumption in humans: an exploratory nutrigenomics study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1089/omi.2008.0079
dc.subject.keyword Virgin olive oil
dc.subject.keyword VOO
dc.subject.keyword Mediterranean diet
dc.subject.keyword Atherosclerosis
dc.subject.keyword Peripheral blood mononuclear cells
dc.subject.keyword PBMNC genes
dc.subject.keyword Nutrigenomics
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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