SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements

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Castellano S, Gladyshev V N, Guigó R, Berry M J. SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements. Nucleic acids research. 2008; 36 supl 1: D332-D338. DOI 10.1093/nar/gkm731
http://hdl.handle.net/10230/13147
To cite or link this document: http://hdl.handle.net/10230/13147
dc.contributor.author Castellano, Sergi
dc.contributor.author Gladyshev, Vadim N.
dc.contributor.author Guigó Serra, Roderic
dc.contributor.author Berry, Marla J.
dc.contributor.other Universitat Pompeu Fabra
dc.date.accessioned 2011-11-28T11:08:03Z
dc.date.available 2011-11-28T11:08:03Z
dc.date.issued 2008
dc.identifier.citation Castellano S, Gladyshev V N, Guigó R, Berry M J. SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements. Nucleic acids research. 2008; 36 supl 1: D332-D338. DOI 10.1093/nar/gkm731
dc.identifier.issn 0305-1048
dc.identifier.uri http://hdl.handle.net/10230/13147
dc.description.abstract Selenoproteins are a diverse group of proteins usually misidentified and misannotated in sequence databases. The presence of an in-frame UGA (stop) codon in the coding sequence of selenoprotein genes precludes their identification and correct annotation. The in-frame UGA codons are recoded to cotranslationally incorporate selenocysteine, a rare selenium-containing amino acid. The development of ad hoc experimental and, more recently, computational approaches have allowed the efficient identification and characterization of the selenoproteomes of a growing number of species. Today, dozens of selenoprotein families have been described and more are being discovered in recently sequenced species, but the correct genomic annotation is not available for the majority of these genes. SelenoDB is a long-term project that aims to provide, through the collaborative effort of experimental and computational researchers, automatic and manually curated annotations of selenoprotein genes, proteins and SECIS elements. Version 1.0 of the database includes an initial set of eukaryotic genomic annotations, with special emphasis on the human selenoproteome, for immediate inspection by selenium researchers or incorporation into more general databases. SelenoDB is freely available at http://www.selenodb.org.
dc.language.iso eng
dc.publisher Oxford University Press
dc.rights (c) 2007 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Published article is also available at http://nar.oxfordjournals.org/content/36/suppl_1/D332.
dc.rights.uri http://creativecommons.org/licenses/by-nc/2.0/uk/
dc.subject.other Biologia molecular
dc.subject.other Bioinformàtica
dc.subject.other Genòmica -- Informàtica
dc.subject.other Genòmica -- Bases de dades
dc.title SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/nar/gkm731
dc.subject.keyword 3'UTR
dc.subject.keyword Protein databases
dc.subject.keyword Genomics
dc.subject.keyword Humans
dc.subject.keyword Internet
dc.subject.keyword Selenoproteins
dc.subject.keyword Protein Sequence Analysis
dc.subject.keyword RNA Sequence Analysis
dc.subject.keyword User-Computer Interface
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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