Multi-receptor binding profile of clozapine and olanzapine: a structural study based on the new beta (2) adrenergic receptor template

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Selent J, López L, Sanz F, Pastor M. Multi-Receptor Binding Profile of Clozapine and Olanzapine: A Structural Study Based on the New β2 Adrenergic Receptor Template. ChemMedChem. 2008; 3(8): 1194-8. DOI 10.1002/cmdc.200800074
http://hdl.handle.net/10230/12425
To cite or link this document: http://hdl.handle.net/10230/12425
dc.contributor.author López Muñoz, Laura
dc.contributor.author Pastor Maeso, Manuel
dc.contributor.author Sanz, Ferran
dc.contributor.author Selent, Jana
dc.date.accessioned 2011-07-27T08:27:56Z
dc.date.available 2011-07-27T08:27:56Z
dc.date.issued 2008
dc.identifier.citation Selent J, López L, Sanz F, Pastor M. Multi-Receptor Binding Profile of Clozapine and Olanzapine: A Structural Study Based on the New β2 Adrenergic Receptor Template. ChemMedChem. 2008; 3(8): 1194-8. DOI 10.1002/cmdc.200800074
dc.identifier.issn 1860-7179
dc.identifier.uri http://hdl.handle.net/10230/12425
dc.description.abstract Schizophrenia is a devastating mental disorder that has a large impact on the quality of life for those who are afflicted and is very costly for families and society.[1] Although the etiology of schizophrenia is still unknown and no cure has yet been found, it is treatable, and pharmacological therapy often produces satisfactory results. Among the various antipsychotic drugs in use, clozapine is widely recognized as one ofthe most clinically effective agents, even if it elicits significant side effects such as metabolic disorders and agranulocytosis. Clozapine and the closely related compound olanzapine are good examples ofdrug s with a complex multi-receptor profile ;[2] they have affinities toward serotonin, dopamine, a adrenergic, muscarinic, and histamine receptors, among others.
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof ChemMedChem. 2008; 3(8): 1194-8
dc.rights © 2008 Wiley-VCH Verlag GmbH& Co. KGaA, Weinheim
dc.subject.other Serotonina
dc.subject.other Esquizofrènia
dc.subject.other Esquizofrènia -- Quimioteràpia
dc.title Multi-receptor binding profile of clozapine and olanzapine: a structural study based on the new beta (2) adrenergic receptor template
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1002/cmdc.200800074
dc.rights.accessRights info:eu-repo/semantics/OpenAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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