Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice

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Balerio GN, Aso E, Maldonado R. Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice. Psychopharmacology. 2006; 184(3-4): 504-13. DOI 10.1007/s00213-005-0251-9
http://hdl.handle.net/10230/12417
To cite or link this document: http://hdl.handle.net/10230/12417
dc.contributor.author Aso Pérez, Ester
dc.contributor.author Balerio, Graciela N.
dc.contributor.author Maldonado, Rafael, 1961-
dc.date.accessioned 2011-07-27T08:27:44Z
dc.date.available 2011-07-27T08:27:44Z
dc.date.issued 2006
dc.identifier.citation Balerio GN, Aso E, Maldonado R. Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice. Psychopharmacology. 2006; 184(3-4): 504-13. DOI 10.1007/s00213-005-0251-9
dc.identifier.issn 0033-3158
dc.identifier.uri http://hdl.handle.net/10230/12417
dc.description.abstract Rationale: Acute behavioural effects and motivational responses induced by nicotine can be modulated by the endocannabinoid system supporting the existence of a physiological interaction between these two systems. Objectives: The present study was designed to examine the possible involvement of the cannabinoid system in the anxiolytic- and anxiogenic-like responses induced by nicotine in mice. Methods: Animals were only exposed once to nicotine. The acute administration of low (0.05, sc) or high (0.8 mg/kg, sc) doses of nicotine produced opposite effects in the elevated plus-maze, i.e., anxiolytic- and anxiogenic-like responses, respectively. The effects of the pretreatment with the CB1 cannabinoid receptor antagonist, rimonabant (0.25, 0.5 and 1 mg/kg, ip), and the cannabinoid agonist, 9-tetrahydrocannabinol (0.1 mg/kg, ip), were evaluated on the anxiolytic- and anxiogenic-like responses induced by nicotine. Results: Rimonabant completely abolished nicotine-induced anxiolytic-like effects and increased the anxiogenic-like responses of nicotine, suggesting an involvement of CB1 receptors in these behavioural responses. On the other hand, 9-tetrahydrocannabinol failed to modify nicotine anxiolytic-like responses, but attenuated its anxiogenic-like effects. In addition the association of non-effective doses of 9-tetrahydrocannabinol and nicotine produced clear anxiolytic-like responses. Conclusions: These results demonstrate that the endogenous cannabinoid system is involved in the regulation of nicotine anxiety-like behaviour in mice, and provide new findings to support the use of cannabinoid antagonists in the treatment of tobacco addiction.
dc.description.sponsorship This work has been supported by grants from National Institutes of Health (1R01-DA016768-0111), Ministerio de Educación y Ciencia (BFU 2004–00920/BFI), Marató TV3, Redes de Centros y Grupos del Instituto de Salud Carlos III (C03/06 and G03/005), Generalitat de Catalunya (2002 SGR00193) and the European Comission (Quality of Life and Management of Living Resources QLRT-2001-01691 LSHM-CT 2004-005166). Graciela Balerio is a post doctoral fellow supported by “Fundación Carolina”.
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Psychopharmacology. 2006; 184(3-4): 504-13
dc.rights (c) Springer. The original publication is available at www.springerlink.com
dc.subject.other Cannabinoides -- Receptors
dc.subject.other Nicotina -- Efectes fisiològics
dc.subject.other Nicotina -- Receptors
dc.subject.other Cannabinoides -- Efectes fisiològics
dc.title Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1007/s00213-005-0251-9
dc.subject.keyword Nicotine
dc.subject.keyword Cannabinoid system
dc.subject.keyword Elevated plus-maze
dc.subject.keyword Anxiety
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/submittedVersion


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