Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice

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Balerio GN, Aso E, Maldonado R. Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice. Psychopharmacology. 2006; 184(3-4): 504-13. DOI 10.1007/s00213-005-0251-9
http://hdl.handle.net/10230/12417
To cite or link this document: http://hdl.handle.net/10230/12417
dc.contributor.author Aso Pérez, Ester
dc.contributor.author Balerio, Graciela N.
dc.contributor.author Maldonado, Rafael
dc.date.accessioned 2011-07-27T08:27:44Z
dc.date.available 2011-07-27T08:27:44Z
dc.date.issued 2006
dc.identifier.citation Balerio GN, Aso E, Maldonado R. Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice. Psychopharmacology. 2006; 184(3-4): 504-13. DOI 10.1007/s00213-005-0251-9
dc.identifier.issn 0033-3158
dc.identifier.uri http://hdl.handle.net/10230/12417
dc.description.abstract Rationale: Acute behavioural effects and motivational responses induced by nicotine can be modulated by the endocannabinoid system supporting the existence of a physiological interaction between these two systems. Objectives: The present study was designed to examine the possible involvement of the cannabinoid system in the anxiolytic- and anxiogenic-like responses induced by nicotine in mice. Methods: Animals were only exposed once to nicotine. The acute administration of low (0.05, sc) or high (0.8 mg/kg, sc) doses of nicotine produced opposite effects in the elevated plus-maze, i.e., anxiolytic- and anxiogenic-like responses, respectively. The effects of the pretreatment with the CB1 cannabinoid receptor antagonist, rimonabant (0.25, 0.5 and 1 mg/kg, ip), and the cannabinoid agonist, 9-tetrahydrocannabinol (0.1 mg/kg, ip), were evaluated on the anxiolytic- and anxiogenic-like responses induced by nicotine. Results: Rimonabant completely abolished nicotine-induced anxiolytic-like effects and increased the anxiogenic-like responses of nicotine, suggesting an involvement of CB1 receptors in these behavioural responses. On the other hand, 9-tetrahydrocannabinol failed to modify nicotine anxiolytic-like responses, but attenuated its anxiogenic-like effects. In addition the association of non-effective doses of 9-tetrahydrocannabinol and nicotine produced clear anxiolytic-like responses. Conclusions: These results demonstrate that the endogenous cannabinoid system is involved in the regulation of nicotine anxiety-like behaviour in mice, and provide new findings to support the use of cannabinoid antagonists in the treatment of tobacco addiction.
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Psychopharmacology. 2006; 184(3-4): 504-13
dc.rights (c) Springer. The original publication is available at www.springerlink.com
dc.subject.other Cannabinoides -- Receptors
dc.subject.other Nicotina -- Efectes fisiològics
dc.subject.other Nicotina -- Receptors
dc.subject.other Cannabinoides -- Efectes fisiològics
dc.title Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1007/s00213-005-0251-9
dc.subject.keyword Nicotine
dc.subject.keyword Cannabinoid system
dc.subject.keyword Elevated plus-maze
dc.subject.keyword Anxiety
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/submittedVersion


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