Mostra el registre parcial de l'element
dc.contributor.author | López Muñoz, Laura |
dc.contributor.author | Aranda, Reyes |
dc.contributor.author | Villalba, Karen |
dc.contributor.author | Raviña, Enrique |
dc.contributor.author | Masaguer, Christian F. |
dc.contributor.author | Brea, José |
dc.contributor.author | Areias, Filipe |
dc.contributor.author | Domínguez, Eduardo |
dc.contributor.author | Selent, Jana |
dc.contributor.author | Sanz, Ferran |
dc.contributor.author | Loza, María I. |
dc.contributor.author | Pastor Maeso, Manuel |
dc.date.accessioned | 2011-07-12T07:04:17Z |
dc.date.available | 2011-07-12T07:04:17Z |
dc.date.issued | 2008 |
dc.identifier.citation | Aranda R, Villalba K, Raviña E, Masaguer CF, Brea J, Areias F et al. Synthesis, Binding Affinity, and Molecular Docking Analysis of New Benzofuranone Derivatives as Potential Antipsychotics. J Med Chem. 2008;51(19):6085-94. DOI: 10.1021/jm800602w |
dc.identifier.issn | 0022-2623 |
dc.identifier.uri | http://hdl.handle.net/10230/12402 |
dc.description.abstract | The complex etiology of schizophrenia has prompted researchers to develop clozapine-related multitarget/nstrategies to combat its symptoms. Here we describe a series of new 6-aminomethylbenzofuranones in an/neffort to find new chemical structures with balanced affinities for 5-HT2 and dopamine receptors. Through/nbiological and computational studies of 5-HT2A and D2 receptors, we identified the receptor serine residues/nS3.36 and S5.46 as the molecular keys to explaining the differences in affinity and selectivity between/nthese new compounds for this group of receptors. Specifically, the ability of these compounds to establish/none or two H-bonds with these key residues appears to explain their difference in affinity. In addition, we/ndescribe compound 2 (QF1004B) as a tool to elucidate the role of 5-HT2C receptors in mediating antipsychotic/neffects and metabolic adverse events. The compound 16a (QF1018B) showed moderate to high affinities/nfor D2 and 5-HT2A receptors, and a 5-HT2A/D2 ratio was predictive of an atypical antipsychotic profile. |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | American Chemical Society (ACS) |
dc.relation.ispartof | Journal of Medicinal Chemistry. 2008;51(9):6085-94 |
dc.rights | © American Chemical Society (ACS) |
dc.subject.other | Psicofàrmacs |
dc.title | Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivative as pontential antipsychotics |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.1021/jm800602w |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/publishedVersion |