On the association between chromosomal rearragements and genic evolution in mammals

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Marques-Bonet T, Sànchez-Ruiz J, Armengol L, Khaja R, Bertranpetit J, Lopez-Bigas N, Rocchi M, Gazave E, Navarro A. On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees. Genome Biology. 2007 October; 8(10): R230.
http://hdl.handle.net/10230/11959
dc.contributor.author Marquès i Bonet, Tomàs, 1975-
dc.contributor.author Sànchez Ruiz, Jesús
dc.contributor.author Armengol i Bernils, Lluís
dc.contributor.author Khaja, Razi
dc.contributor.author Bertranpetit, Jaume, 1952-
dc.contributor.author López Bigas, Núria
dc.contributor.author Rocchi, Mariano
dc.contributor.author Gazave, Elodie
dc.contributor.other Navarro i Cuartiellas, Arcadi, 1969-
dc.date.accessioned 2013-07-12T01:50:18Z
dc.date.available 2013-07-12T01:50:18Z
dc.date.issued 2007-01-15
dc.identifier.citation Marques-Bonet T, Sànchez-Ruiz J, Armengol L, Khaja R, Bertranpetit J, Lopez-Bigas N, Rocchi M, Gazave E, Navarro A. On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees. Genome Biology. 2007 October; 8(10): R230.
dc.identifier.uri http://hdl.handle.net/10230/11959
dc.description.abstract Background: The role that chromosomal rearrangements might have played in the speciation processes that have separated the lineages of humans and chimpanzees has recently come into the spotlight. To date, however, results are contradictory. Here we revisit this issue by making use of the available human and chimpanzee genome sequence to study the relationship between chromosomal rearrangements and rates of DNA sequence evolution. Results. Contrary to previous findings for this pair of species, we show that genes located in the rearranged chromosomes that differentiate the genomes of humans and chimpanzees, especially genes within rearrangements themselves, present lower divergence than genes elsewhere in the genome. Still, there are considerable differences between individual chromosomes. Chromosome 4, in particular, presents higher divergence in genes located within its rearrangement. Conclusion: A first conclusion of our analysis is that divergence is lower for genes located in rearranged chromosomes than for those in colinear chromosomes. We also report that non-coding regions within rearranged regions tend to have lower divergence than non-coding regions outside them. These results suggest an association between chromosomal rearrangements and lower non-coding divergence that has not been reported before, even if some chromosomes do not follow this trend and could be potentially associated with a speciation episode. In summary, without excluding it, our results suggest that chromosomal speciation has not been common along the human and chimpanzee lineage.
dc.description.sponsorship This research was supported by grants to AN from the Ministerio de Ciencia y Tecnologia (Spain, BOS2003-0870 and BFU2006 15413-C02-01); the Genome Canada-Genoma España Joint R+D+I Projects in Human Health (JLI/038) and the National Institute of Bioinformatics http://www.inab.org, a platform of Genoma España. T M-B is a research fellow supported by Departament d'Educacio i Universitats de la Generalitat de Catalunya.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Universitat Pompeu Fabra
dc.relation.ispartof Genome Biology. 2007 October; 8(10): R230.
dc.rights ADVERTIMENT. L'accés als continguts d'aquesta tesi doctoral i la seva utilització ha de respectar els drets de la persona autora. Pot ser utilitzada per a consulta o estudi personal, així com en activitats o materials d'investigació i docència en els termes establerts a l'art. 32 del Text Refós de la Llei de Propietat Intel·lectual (RDL 1/1996). Per altres utilitzacions es requereix l'autorització prèvia i expressa de la persona autora. En qualsevol cas, en la utilització dels seus continguts caldrà indicar de forma clara el nom i cognoms de la persona autora i el títol de la tesi doctoral. No s'autoritza la seva reproducció o altres formes d'explotació efectuades amb finalitats de lucre ni la seva comunicació pública des d'un lloc aliè al servei TDX. Tampoc s'autoritza la presentació del seu contingut en una finestra o marc aliè a TDX (framing). Aquesta reserva de drets afecta tant als continguts de la tesi com als seus resums i índexs.
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/2.0
dc.subject.other Cromosomes
dc.subject.other Mamífers
dc.subject.other Genètica evolutiva
dc.subject.other Expressió genètica
dc.title On the association between chromosomal rearragements and genic evolution in mammals
dc.date.modified 2013-07-10T11:29:06Z
dc.identifier.doi http://dx.doi.org/10.1186/gb-2007-8-10-r230

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